公开(公告)号：US10196411B2

公开(公告)日：2019-02-05

申请号：US15539266

申请日：2015-12-11

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

发明人： Song Li ,  Xingzhou Li ,  Wu Zhong ,  Zhibing Zheng ,  Junhai Xiao ,  Xinbo Zhou ,  Yunde Xie ,  Xiaokui Wang ,  Lili Wang ,  Wei Chen ,  Fei Xie

IPC分类号： C07D277/58 ,  C07F9/6539 ,  A61K31/426 ,  A61K31/675 ,  A61P31/20 ,  A61P31/14 ,  A61P31/16 ,  A61P31/06 ,  A61P33/02 ,  A61P33/04 ,  A61P33/10 ,  A61P1/00

摘要： The invention relates to tizoxanide phosphate or alkane sulfonate compounds represented by Formula I, and pharmaceutically acceptable salts thereof, isomers thereof, hydrates thereof or solvates thereof, and pharmaceutical applications of the compounds.

公开(公告)号：US10131643B2

公开(公告)日：2018-11-20

申请号：US14901805

申请日：2014-07-04

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

发明人： Song Li ,  Xingzhou Li ,  Wu Zhong ,  Zhibing Zheng ,  Junhai Xiao ,  Xinbo Zhou ,  Yunde Xie ,  Xiaokui Wang ,  Lili Wang ,  Wei Chen ,  Fei Xie

IPC分类号： C07D277/58 ,  C07D401/12 ,  C07D417/12

摘要： The invention relates to a tizoxanide carbamate compound of Formula I and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and their pharmaceutical use.