公开(公告)号：US09944932B2

公开(公告)日：2018-04-17

申请号：US14849777

申请日：2015-09-10

Applicant: InteRNA Technologies B.V.

Inventor： Roeland Quirinus Jozef Schaapveld ,  Gerardus Wilhelmus Christiaan Theodoor Verhaegh ,  Jacobus Antonius Schalken ,  Andreas Alphons Franciscus Ludovicus van Puijenbroek ,  Willemijn Maria Gommans ,  Sanne Weijzen

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7105 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10

CPC classification number: C12N15/1138 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2330/10

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).