公开(公告)号：US20200215063A1

公开(公告)日：2020-07-09

申请号：US16820794

申请日：2020-03-17

Applicant: Intelgenx Corp.

Inventor： Horst G. Zerbe ,  Nadine Paiement ,  Angela Angusti ,  Cormac Long ,  Rodolphe Obeid ,  Laetitia Rodes ,  Billal Tir

IPC: A61K31/4985 ,  A61K9/00 ,  A61K9/70

Abstract: Oral film dosage forms that provide improved solubilization and stabilization of an active ingredient in particle form include at least one primary crystallization inhibitor in an amount that inhibits growth and/or agglomeration of the active ingredient, a polyoxyethylated fatty acid glycerides in an amount that further enhances inhibition of crystallization, growth and agglomeration of the particles of the pharmaceutically active ingredient; and at least one plasticizer present in an amount that is effective to increase flexibility and elasticity of the film dosage form.