公开(公告)号：US20230073821A1

公开(公告)日：2023-03-09

申请号：US17459486

申请日：2021-08-27

申请人： International Business Machines Corporation

发明人： Binquan Luan ,  Leili Zhang ,  Tien Huynh

IPC分类号： C07K16/10

摘要： Techniques regarding antigen-binding proteins that can bind to CoV (e.g., SARS-CoV-2) variants are provided. For example, one or more embodiments described herein can comprise an antigen-binding protein that can comprise a heavy polypeptide chain variable region with an amino acid sequence that is a variant of SEQ ID NO: 7. The amino acid sequence can comprise at least one amino acid substitution selected from the group consisting of: R50D, R50E, R50W, R50F, R50Y, R50L, R50V, R50I, R50Pho, I54D, I54E, I54W, I54F, I54Y, I54Pho, L55D, L55E, L55W, L55F, L55Y, and L55Pho.