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公开(公告)号:US12173010B2
公开(公告)日:2024-12-24
申请号:US18316471
申请日:2023-05-12
Applicant: INVENTISBIO CO., LTD.
Inventor: Xing Dai , Yaolin Wang , Yueheng Jiang , Yanqin Liu , Haotao Niu , Zhenwu Wang , Zixing Han , Liangshan Tao , Jifang Weng , Zhe Shi
IPC: C07D493/08 , A61K31/00 , C07D401/14 , C07D405/14 , C07D417/14 , C07D487/04
Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.
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公开(公告)号:US12110289B2
公开(公告)日:2024-10-08
申请号:US17365503
申请日:2021-07-01
Applicant: InventisBio Co., Ltd.
Inventor: Xing Dai , Yaolin Wang , Yueheng Jiang , Yanqin Liu , Zhe Shi , Zhenwu Wang , Liangshan Tao , Zixing Han , Haotao Niu , Jifang Weng
IPC: C07D471/04 , A61K31/282 , A61K31/438 , A61K31/519 , A61K33/243 , A61P35/00 , C07D519/00
CPC classification number: C07D471/04 , A61K31/282 , A61K31/438 , A61K31/519 , A61K33/243 , A61P35/00 , C07D519/00
Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).
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公开(公告)号:US11691981B2
公开(公告)日:2023-07-04
申请号:US16910878
申请日:2020-06-24
Applicant: INVENTISBIO CO., LTD.
Inventor: Xing Dai , Yaolin Wang , Yueheng Jiang , Yanqin Liu , Haotao Niu , Zhenwu Wang , Zixing Han , Liangshan Tao , Jifang Weng , Zhe Shi
IPC: C07D493/08 , C07D401/14 , C07D405/14 , C07D417/14 , C07D487/04
CPC classification number: C07D493/08 , C07D401/14 , C07D405/14 , C07D417/14 , C07D487/04
Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.
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