专利检索 ap:("Iowa State University Research Foundation, Inc.") AND inv:"Krishna K. Sharma" 第 1 页

1.

发明公开
FORMATION OF AMIDINES AND INTRAMOLECULAR REACTION THEREOF 审中-公开

公开(公告)号：US20240300888A1

公开(公告)日：2024-09-12

申请号：US18598811

申请日：2024-03-07

申请人： Iowa State University Research Foundation, Inc.

发明人： Brett VanVeller , Emily O'Brien , Krishna K. Sharma , Jacob Byerly-Duke , Brendan J. Wall

IPC分类号： C07C249/16 , C07C323/45 , C07D233/70 , C07K1/00

CPC分类号： C07C249/16 , C07C323/45 , C07D233/70 , C07K1/003

摘要： A method of conversion of thioimidates into amidines includes reacting a starting material compound including a thioimidate with a nitrogen-containing reagent to form a product compound including an amidine in place of the thioimidate in the starting material compound. The nitrogen-containing reagent includes a primary amine, a secondary amine, an ammonium salt, or a combination thereof. The thioimidate includes —S—R1, wherein R1 is substituted or unsubstituted (C1-C20)hydrocarbyl. A method of forming a cyclized product includes intramolecularly reacting an amidine with a carbonyl carbon to form the cyclized product including a 4H-imidazolone and/or a derivative thereof.