公开(公告)号：US10087432B2

公开(公告)日：2018-10-02

申请号：US14423222

申请日：2012-11-21

Applicant: Ipsen BioInnovation, Ltd.

Inventor： Andreas Rummel

IPC: C12N9/50 ,  C07K14/33 ,  C12Q1/37

Abstract: The present invention relates to a novel proteolytically active polypeptide and various uses of the polypeptide (and others) in screening and manufacturing methods.

公开(公告)号：US09650622B2

公开(公告)日：2017-05-16

申请号：US14451984

申请日：2014-08-05

Applicant: Ipsen Bioinnovation, Ltd.

Inventor： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

IPC: A61K39/08 ,  C12N9/52 ,  C07K14/33 ,  A61K38/00

CPC classification number: C12N9/52 ,  A61K38/00 ,  C07K14/33 ,  C12Y304/24069 ,  Y02A50/469 ,  Y02A50/473

Abstract: The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragm assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.