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公开(公告)号：US08450067B2
公开(公告)日：2013-05-28
申请号：US10515499
申请日：2003-05-22
申请人： Israel Nur , Yehuda Shoenfeld , Miri Blank
发明人： Israel Nur , Yehuda Shoenfeld , Miri Blank
IPC分类号： G01N33/53
CPC分类号： C07K16/4241 , A61K38/06 , A61K38/12 , A61K39/00 , C07K7/06 , C07K16/065 , C07K16/18 , C07K2317/565 , C40B30/04 , G01N33/564 , G01N33/686 , G01N2500/04 , G01N2800/24 , Y02A50/401 , Y02A50/414
摘要： A method for identifying molecules which mimic an idiotype of an autoimmune disease-associated auto-antibody (autoantibodies). The method comprises the following steps: (a) purifying autoantibodies from sera of one or more patients afflicted with the autoimmune disease; (b) binding the autoantibodies to a solid phase to form an affinity matrix; (c) contacting pooled plasma or B cells comprising immunoglobulins with the affinity matrix followed by removal of unbound plasma components; (d) eluting bound immunoglobulins, being anti-Idiotypic antibodies (anti-Id) to autoantibodies, from the matrix; (e) providing a molecular library comprising a plurality of molecule members; and (e) contacting the anti-Id with the molecular library and isolating those bound molecules which are bound by the anti-Id, the bound molecules being molecules which mimic an idiotype of autoantibodies. Also disclosed are such molecules.
摘要翻译： 用于鉴定模拟自身免疫性疾病相关自身抗体（自身抗体）的独特型的分子的方法。 该方法包括以下步骤：（a）从患有自身免疫性疾病的一种或多种患者的血清中纯化自身抗体; （b）将自身抗体结合到固相以形成亲和基质; （c）使包含免疫球蛋白的合并血浆或B细胞与亲和基质接触，然后除去未结合的血浆成分; （d）从基质中洗脱结合的免疫球蛋白，作为自身抗体的抗独特型抗体（抗-Id）; （e）提供包含多个分子成员的分子文库; 和（e）使抗-Id与分子文库接触并分离由抗-Id结合的结合分子，结合分子是模拟自身抗体的独特型的分子。 还公开了这样的分子。
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2.发明授权Synthetic peptides and pharmaceutical compositions comprising them for diagnosis and treatment of anti-phospholipid syndrome 失效包含它们的合成肽和药物组合物用于诊断和治疗抗磷脂综合征公开(公告)号：US06825319B1
公开(公告)日：2004-11-30
申请号：US09743225
申请日：2001-01-08
IPC分类号： C07K700
CPC分类号： C07K14/775 , A61K38/00
摘要： Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (&bgr;2GPI) monoclonal antibodies (mabs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-&bgr;2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.
摘要翻译： 能够在体外抑制抗β-2-糖蛋白1（β2GPI）单克隆抗体（mabs）的生物学活性的合成肽及其衍生物，并通过抗β2GPI抑制小鼠实验性抗磷脂综合征（APS）的诱导 mAbs，用于诊断和治疗人类的抗磷脂综合征。
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公开(公告)号：US20070166313A1
公开(公告)日：2007-07-19
申请号：US11606364
申请日：2006-11-30
申请人： Yehuda Shoenfeld , Miri Blank
发明人： Yehuda Shoenfeld , Miri Blank
IPC分类号： A61K39/395
CPC分类号： A61K39/39558
摘要： This invention relates to cancer therapy and in particular to the administration of gamma globulins to inhibit both primary tumor and metastasis and augment treatment of primary cancerous tumors. In accordance with this invention, the treatment of various cancerous diseases is accomplished by administering a preparation containing intact gamma globulins or fragments thereof.
摘要翻译： 本发明涉及癌症治疗，特别涉及γ球蛋白的施用以抑制原发性肿瘤和转移以及增加原发性癌性肿瘤的治疗。 根据本发明，通过施用含有完整的γ球蛋白或其片段的制剂来实现各种癌性疾病的治疗。
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公开(公告)号：US20100260760A1
公开(公告)日：2010-10-14
申请号：US12617603
申请日：2009-11-12
申请人： Miri Blank , Yehuda Shoenfeld
发明人： Miri Blank , Yehuda Shoenfeld
IPC分类号： A61K39/395 , A61P35/04 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/76
摘要： This invention relates to IVIG and fragments thereof and their use, specifically, provided herein are compositions and methods of inhibiting VEGF or VEGF receptor using polyclonal antibodies (pAb), or fragments thereof derived from human immunoglobulins.
摘要翻译： 本发明涉及IVIG及其片段及其用途，具体地，本文提供了使用多克隆抗体（pAb）或其衍生自人免疫球蛋白的片段抑制VEGF或VEGF受体的组合物和方法。
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公开(公告)号：US20090053217A1
公开(公告)日：2009-02-26
申请号：US12149766
申请日：2008-05-07
申请人： Miri Blank , Yehuda Shoenfeld
发明人： Miri Blank , Yehuda Shoenfeld
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/76
摘要： This invention relates to IVIG and fragments thereof and their use, specifically, provided herein are compositions and methods of inhibiting VEGF or VEGF receptor using polyclonal antibodies (pAb), or fragments thereof derived from human immunoglobulins.
摘要翻译： 本发明涉及IVIG及其片段及其用途，具体地，本文提供了使用多克隆抗体（pAb）或其衍生自人免疫球蛋白的片段抑制VEGF或VEGF受体的组合物和方法。
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公开(公告)号：US20080050390A1
公开(公告)日：2008-02-28
申请号：US11646572
申请日：2006-12-28
申请人： Yehuda Shoenfeld , Miri Blank
发明人： Yehuda Shoenfeld , Miri Blank
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/06 , A01K2267/0331 , C07K2317/55
摘要： This invention relates to cancer therapy and in particular to the administration of gamma globulins to inhibit both primary tumor and metastasis and augment treatment of primary cancerous tumors. In accordance with this invention, the treatment of various cancerous diseases is accomplished by administering a preparation containing intact gamma globulins or fragments thereof.
摘要翻译： 本发明涉及癌症治疗，特别涉及γ球蛋白的施用以抑制原发性肿瘤和转移以及增加原发性癌性肿瘤的治疗。 根据本发明，通过施用含有完整的γ球蛋白或其片段的制剂来实现各种癌性疾病的治疗。
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7.发明授权公开(公告)号：US07053178B2
公开(公告)日：2006-05-30
申请号：US10997989
申请日：2004-11-29
IPC分类号： C07K7/00
CPC分类号： C07K14/775 , A61K38/00
摘要： Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (β2GPI) monoclonal antibodies (mAbs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-β2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.
摘要翻译： 能够在体外抑制抗β-2-糖蛋白1（β2GPI）单克隆抗体（mAb）的生物学活性的合成肽及其衍生物，并通过抗β2GPI抑制小鼠实验性抗磷脂综合征（APS）的诱导 mAbs，用于诊断和治疗人类的抗磷脂综合征。
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8.发明申请公开(公告)号：US20050107584A1
公开(公告)日：2005-05-19
申请号：US10997989
申请日：2004-11-29
IPC分类号： A61K38/00 , C07K14/775 , C07K7/08 , C07K7/06 , G01N33/53
CPC分类号： C07K14/775 , A61K38/00
摘要： Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (β2GPI) monoclonal antibodies (mAbs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-β2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.
摘要翻译： 能够在体外抑制抗β-2-糖蛋白1（β2GPI）单克隆抗体（mAb）的生物学活性的合成肽及其衍生物，并通过抗β2GPI抑制小鼠实验性抗磷脂综合征（APS）的诱导 mAbs，用于诊断和治疗人类的抗磷脂综合征。
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公开(公告)号：US20060078943A1
公开(公告)日：2006-04-13
申请号：US10515499
申请日：2003-05-22
申请人： Israel Nur , Yehuda Shoenfeld
发明人： Israel Nur , Yehuda Shoenfeld
IPC分类号： C40B40/10
CPC分类号： C07K16/4241 , A61K38/06 , A61K38/12 , A61K39/00 , C07K7/06 , C07K16/065 , C07K16/18 , C07K2317/565 , C40B30/04 , G01N33/564 , G01N33/686 , G01N2500/04 , G01N2800/24 , Y02A50/401 , Y02A50/414
摘要： A method for identifying molecules which mimic an idiotype of an autoimmune disease-associated auto-antibody (autoantibodies). The method comprises the following steps: (a) purifying autoantibodies from sera of one or more patients afflicted with the autoimmune disease; (b) binding the autoantibodies to a solid phase to form an affinity matrix; (c) contacting pooled plasma or B cells comprising immunoglobulins with the affinity matrix followed by removal of unbound plasma components; (d) eluting bound immunoglobulins, being anti-Idiotypic antibodies (anti-Id) to autoantibodies, from the matrix; (e) providing a molecular library comprising a plurality of molecule members; and (e) contacting the anti-Id with the molecular library and isolating those bound molecules which are bound by the anti-Id, the bound molecules being molecules which mimic an idiotype of autoantibodies. Also disclosed are such molecules.
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10.发明申请Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of vascular disease 审中-公开含有β2-糖蛋白I的组合物用于预防和/或治疗血管疾病公开(公告)号：US20050197283A1
公开(公告)日：2005-09-08
申请号：US11106665
申请日：2005-04-15
申请人： Dror Harats , Yehuda Shoenfeld , Niva Yacov , Jacob George
发明人： Dror Harats , Yehuda Shoenfeld , Niva Yacov , Jacob George
IPC分类号： A61K38/17 , A61K45/06 , A61K39/00 , A61K31/401
CPC分类号： A61K38/1709 , A61K45/06
摘要： Methods and compositions employing beta2-glycoprotein-1 (β2GPI) or derivatives of β2GPI effective in inducing mucosal tolerance to atheroma related antigens, thus inhibiting inflammatory processes contributing to atheromatous vascular disease and sequalae, are provided. Also provided are articles of manufacture comprising mucosal tolerance inducing amounts of beta2-glycoprotein-1 46 (β2GPI) or derivatives thereof.
摘要翻译： 使用β2 - 2 - 糖蛋白-1（β2 GPI）或β2βGPI衍生物的方法和组合物有效诱导与动脉粥样化相关的粘膜耐受性 提供抗原，从而抑制有助于动脉粥样化血管疾病和后遗症的炎症过程。 还提供了包含粘膜耐受诱导量的β2 - 糖蛋白-1 46（β2 GPI）或其衍生物的制品。
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