公开(公告)号：US06498180B1

公开(公告)日：2002-12-24

申请号：US09979322

申请日：2001-11-16

申请人： Ivan Collado Cano ,  Concepcion Pedregal Tercero ,  Alicia Marcos Llorente ,  Beatriz Lopez de Uralde Garmendia ,  Maria Rosario Gonzalez Garcia ,  Ana Belen Bueno Melendo

发明人： Ivan Collado Cano ,  Concepcion Pedregal Tercero ,  Alicia Marcos Llorente ,  Beatriz Lopez de Uralde Garmendia ,  Maria Rosario Gonzalez Garcia ,  Ana Belen Bueno Melendo

IPC分类号： C01D31190

CPC分类号： C07C229/28 ,  C07B2200/07 ,  C07C2601/02

摘要： Compounds of formula (I) in which R1 is halo-C1-10 alkyl; halo-C2-10 alkenyl; or (CH2)nY in which n is 1 or 2 and Y is OH, CN, N3, OR3, SH, S(O)pR4, S(O)3H, NH2, NHR5, NR6R7, NHCOR8, NO2, CO2H, CONHR9, 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl or PO3H2; R3, R5, R6, R7, R8 and R9 are each selected independently from C1-4 alkyl, aryl and aryl-C1-4 alkyl; R4 is selected from C1-4 alkyl, aryl, aryl-C1-4 alkyl, and 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C1-4 alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R1 is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.

摘要翻译： 其中R 1为卤代C 1-10烷基的式（I）化合物; 卤代-C2-10烯基; 或其中n为1或2且Y为OH，CN，N 3，OR 3，SH，S（O）p R 4，S（O）3 H，NH 2，NHR 5，NR 6 R 7，NHCOR 8，NO 2，CO 2 H，CONHR 9的（CH 2）n Y ，1H-四唑-5-基，5-苯基四唑-2-基或PO 3 H 2; R 3，R 5，R 6，R 7，R 8和R 9各自独立地选自C 1-4烷基，芳基和芳基-C 1-4烷基; R 4选自C 1-4烷基，芳基，芳基-C 1-4烷基和1H-四唑-5-基，羧基 - （1-4C）烷基和1H-四唑-5-基-C 1-4烷基; p为0,1,2或3; 或其盐或酯，条件是R1不是甲氧基甲基，调节代谢型谷氨酸受体功能，并且可用于治疗中枢神经系统的病症。