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1.发明授权
公开(公告)号：US05997530A
公开(公告)日：1999-12-07
申请号：US59537
申请日：1998-04-13
CPC分类号： A61B90/04 , A61B18/0218 , A61B18/203 , A61B2018/00029 , A61B2018/00452 , A61B2090/049
摘要： Cryogen spray cooling of skin surface with millisecond cryogen spurts is an effective method for establishing a controlled temperature distribution in tissue and protecting the epidermis from nonspecific thermal injury during laser mediated dermatological procedures. Control of humidity level, spraying distance and cryogen boiling point is material to the resulting surface temperature. Decreasing the ambient humidity level results in less ice formation on the skin surface without altering the surface temperature during the cryogen spurt. For a particular delivery nozzle, increasing the spraying distance to 85 millimeters lowers the surface temperature. The methodology comprises establishing a controlled humidity level in the theater of operation of the irradiation site of the biological tissues before and/or during the cryogenic spray cooling of the biological tissue. At cold temperatures calibration was achieved by mounting a thermistor on a thermoelectric cooler. The thermal electric cooler was cooled from from 20.degree. C. to about -20.degree. C. while measuring its infrared emission.
摘要翻译： 皮肤表面的低温喷雾冷却与毫秒制冷剂喷雾是在激光介导的皮肤病学程序中建立组织中受控温度分布并保护表皮免受非特异性热损伤的有效方法。 控制湿度水平，喷涂距离和冷冻剂沸点是所得表面温度的物质。 降低环境湿度水平导致皮肤表面上冰层形成较少，而不会在冷冻剂喷溅期间改变表面温度。 对于特定的输送喷嘴，将喷涂距离增加到85毫米会降低表面温度。 该方法包括在生物组织的低温喷雾冷却之前和/或期间在生物组织的照射部位的操作剧场中建立受控的湿度水平。 在寒冷的温度下，通过在热电冷却器上安装热敏电阻来实现校准。 将热电冷却器从20℃冷却至约-20℃，同时测量其红外发射。
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