公开(公告)号：US20190127378A1

公开(公告)日：2019-05-02

申请号：US16307827

申请日：2017-06-07

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Cunbo MA ,  Panliang GAO ,  Jie CHU ,  Xinping WU ,  Chunwei WEN ,  Di KANG ,  Jinlong BAI ,  Xiaoyan PEI

IPC: C07D471/14 ,  C07D491/107 ,  C07D471/20 ,  C07D413/14 ,  C07D401/04 ,  C07D401/14 ,  A61P35/00

Abstract: Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.