公开(公告)号：US11466005B2

公开(公告)日：2022-10-11

申请号：US17561381

申请日：2021-12-23

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Haiquan Fang ,  Mingming Chen ,  Guiqun Yang ,  Yuelei Du ,  Yanping Wang ,  Tong Wu ,  Qinglong Li ,  Lei Zhang ,  Shaojing Hu

IPC: C07D471/14 ,  A61K31/437 ,  A61P35/00

Abstract: Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.

公开(公告)号：US20250011327A1

公开(公告)日：2025-01-09

申请号：US18818701

申请日：2024-08-29

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Haiquan FANG ,  Mingming Chen ,  Guiqun Yang ,  Yuelei Du ,  Yanping Wang ,  Tong Wu ,  Qinglong Li ,  Lei Zhang ,  Shaojing Hu

IPC: C07D471/14 ,  A61P35/00

Abstract: Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.

公开(公告)号：US12103929B2

公开(公告)日：2024-10-01

申请号：US17129983

申请日：2020-12-22

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Haiquan Fang ,  Mingming Chen ,  Guiqun Yang ,  Yuelei Du ,  Yanping Wang ,  Tong Wu ,  Qinglong Li ,  Lei Zhang ,  Shaojing Hu

IPC: C07D471/14 ,  A61P35/00

CPC classification number: C07D471/14 ,  A61P35/00 ,  C07B2200/05

Abstract: Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.