公开(公告)号：US20160235813A1

公开(公告)日：2016-08-18

申请号：US15023108

申请日：2014-09-18

Applicant: JAMES COOK UNIVERSITY

Inventor： Cinzia Cantacessi ,  Alex Loukas

IPC: A61K38/17 ,  A61K45/06

CPC classification number: A61K38/1767 ,  A61K38/1709 ,  A61K38/57 ,  A61K45/06

Abstract: A method and composition for reducing or alleviating inflammation in a subject is provided, including administering to the subject a therapeutically effective amount; of one or more isolated proteins respectively comprising an amino acid sequence set forth in SEQ ID NOS:1-31, or a biologically active fragment or variant thereof or combinations of these to thereby reduce or alleviate inflammation. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

Abstract translation: 提供了用于减少或减轻受试者的炎症的方法和组合物，包括向受试者施用治疗有效量; 分别包含SEQ ID NO：1-31所示的氨基酸序列的一个或多个分离的蛋白质，或其生物活性片段或变体或它们的组合，从而减少或减轻炎症。 炎症可能与疾病相关，是消化道疾病，如慢性胃炎或炎症性肠病如克罗恩病或溃疡性结肠炎，或呼吸系统疾病，如哮喘，肺气肿，慢性支气管炎和慢性疾病 阻塞性肺疾病。