公开(公告)号：US20160229905A1

公开(公告)日：2016-08-11

申请号：US15023165

申请日：2014-09-18

Applicant: JAMES COOK UNIVERSITY

Inventor： Alex Loukas ,  Andrew Leech ,  Darren Pickering

IPC: C07K14/81 ,  A61K45/06 ,  A61K38/57

Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

Abstract translation: 改良的Ac-TMP-2蛋白缺乏通常存在于全长或野生型Ac-TMP-2蛋白质中的一个或多个酸性C末端氨基酸，并且也可能缺少一个或多个N-末端氨基 酸，同时保留N-末端或其附近的氨基酸序列C-S-C。 修饰的Ac-TMP-2蛋白可用于减少或减轻受试者的炎症的方法和组合物。 炎症可能与疾病相关，是消化道疾病，如慢性胃炎或炎症性肠病如克罗恩病或溃疡性结肠炎，或呼吸系统疾病，如哮喘，肺气肿，慢性支气管炎和慢性疾病 阻塞性肺疾病。

公开(公告)号：US11976108B2

公开(公告)日：2024-05-07

申请号：US17071563

申请日：2020-10-15

Applicant: James Cook University

Inventor： Alex Loukas ,  Andrew Leech ,  Darren Pickering

IPC: C07K14/81 ,  A61K38/00 ,  A61K38/57 ,  A61K45/06 ,  C07K14/435

CPC classification number: C07K14/81 ,  A61K38/57 ,  A61K45/06 ,  C07K14/4354 ,  C07K14/8146 ,  A61K38/00

Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C-S-C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

公开(公告)号：US20210061886A1

公开(公告)日：2021-03-04

申请号：US17071563

申请日：2020-10-15

Applicant: James Cook University

Inventor： Alex Loukas ,  Andrew Leech ,  Darren Pickering

IPC: C07K14/81 ,  A61K45/06 ,  C07K14/435 ,  A61K38/57

Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C-S-C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

公开(公告)号：US20240400649A1

公开(公告)日：2024-12-05

申请号：US18414112

申请日：2024-01-16

Applicant: James Cook University

Inventor： Alex Loukas ,  Andrew Leech ,  Darren Pickering

IPC: C07K14/81 ,  A61K38/00 ,  A61K38/57 ,  A61K45/06 ,  C07K14/435

Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C-S-C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

公开(公告)号：US10822395B2

公开(公告)日：2020-11-03

申请号：US15023165

申请日：2014-09-18

Applicant: James Cook University

Inventor： Alex Loukas ,  Andrew Leech ,  Darren Pickering

IPC: A61K38/00 ,  A61P29/00 ,  A61K38/16 ,  A61P11/06 ,  C07K14/81 ,  A61K45/06 ,  C07K14/435 ,  A61K38/57

Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.