公开(公告)号：US20150037366A1

公开(公告)日：2015-02-05

申请号：US14384681

申请日：2013-03-13

Applicant: JAMES COOK UNIVERSITY

Inventor： Alex Loukas ,  Severine Navarro

IPC: C07K14/435 ,  A61K39/00 ,  A61K45/06

CPC classification number: C07K14/4354 ,  A61K38/57 ,  A61K39/0003 ,  A61K45/06

Abstract: A method for reducing or alleviating inflammation in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby reduce or alleviate inflammation in the subject. A method for preventing or treating asthma or inflammatory bowel disease in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby prevent or treat asthma or inflammatory bowel disease in the subject. The subject may be a mammal, inclusive of humans.

Abstract translation: 用于减轻或减轻受试者炎症的方法包括向受试者施用治疗有效量的：（a）Ac-TMP-1或Ac-TMP-1的生物活性片段或变体; （b）Ac-TMP-2或Ac-TMP-2的生物活性片段或变体; 或（c）（a）和（b）的组合，从而减少或缓解受试者的炎症。 用于预防或治疗受试者哮喘或炎症性肠病的方法包括向受试者施用治疗有效量的：（a）Ac-TMP-1或Ac-TMP-1的生物活性片段或变体; （b）Ac-TMP-2或Ac-TMP-2的生物活性片段或变体; 或（c）（a）和（b）的组合，从而预防或治疗受试者的哮喘或炎症性肠病。 受试者可以是哺乳动物，包括人类。

公开(公告)号：US09637527B2

公开(公告)日：2017-05-02

申请号：US14384681

申请日：2013-03-13

Applicant: JAMES COOK UNIVERSITY

Inventor： Alex Loukas ,  Severine Navarro

IPC: C07K14/435 ,  A61K38/57 ,  A61K39/00 ,  A61K45/06

CPC classification number: C07K14/4354 ,  A61K38/57 ,  A61K39/0003 ,  A61K45/06

Abstract: A method for reducing or alleviating inflammation in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby reduce or alleviate inflammation in the subject. A method for preventing or treating asthma or inflammatory bowel disease in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby prevent or treat asthma or inflammatory bowel disease in the subject. The subject may be a mammal, inclusive of humans.