公开(公告)号：US20160297764A1

公开(公告)日：2016-10-13

申请号：US15100866

申请日：2014-12-09

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu KANAI ,  Yohei SOMA ,  Tadamasa ARAI ,  Takushi ARAYA

IPC: C07D213/81

CPC classification number: C07D213/81 ,  C07D239/30

Abstract: Provided is a novel compound which has an excellent Aβ aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents —CH2—, —O—, —S—, or —NH—; R1 and R2 are the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and R3 represents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group.

Abstract translation: 提供具有优异的A 2聚集抑制作用的新型化合物，可用作药物。 由式（1）表示的酰胺化合物或其盐，其中Z表示CH或N; A和B相同或不同，各自表示-CH 2 - ， - O - ， - S-或-NH-。 R 1和R 2相同或不同，各自表示支链烷基，支链烯基，任选取代的芳族烃基，任选取代的芳烷基，任选取代的环烷基或任选取代的芳族杂环基; 并且R 3表示支链烷基，支链烯基，任选取代的环烷基或任选取代的芳烷基。