公开(公告)号：US10533173B2

公开(公告)日：2020-01-14

申请号：US15571587

申请日：2016-05-05

Applicant: JIANGSU MICROMEDMARK BIOTECH CO., LTD.

Inventor： Chenyu Zhang ,  Ke Zeng ,  Xi Chen ,  Junfeng Zhang ,  Hongwei Liang

IPC: A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61P35/00

Abstract: Provided are a new precursor miRNA and the applications in tumor therapy thereof. The precursor miRNA, from 5′- to 3′-end thereof, has the structure represented by formula (I). B1 is an anti-miRNA and/or siRNA to be expressed; B2 is a sequence substantially or completely complementary to B1, and B2 is not complementary to C; C is a sequence with stem-loop structure; A1 and A2 are independently hydrogen or optionally a RNA sequence consisting of 4 to 5 bases. The precursor miRNA can be processed to form an anti-miRNA and/or siRNA in hosts.

公开(公告)号：US11304970B2

公开(公告)日：2022-04-19

申请号：US16099006

申请日：2017-05-05

Applicant: JIANGSU MICROMEDMARK BIOTECH CO., LTD.

Inventor： Chenyu Zhang ,  Xi Chen ,  Hongwei Liang ,  Uzair Ur-Rehman

IPC: A61K31/713 ,  A61P35/02 ,  A61K9/00 ,  C12N15/113 ,  A61K48/00

Abstract: Provided are an EGFR gene expression-suppressing siRNA, a precursor sequence of same, and uses thereof.

公开(公告)号：US10982213B2

公开(公告)日：2021-04-20

申请号：US16098960

申请日：2017-05-05

Applicant: JIANGSU MICROMEDMARK BIOTECH CO., LTD.

Inventor： Chenyu Zhang ,  Xi Chen ,  Hongwei Liang ,  Uzair Ur-Rehman ,  Ke Zeng

IPC: C12N15/113 ,  A61K31/7088

Abstract: The present invention discloses an siRNA that inhibits K-RAS gene expression, and the precursor sequences and applications thereof. The K-RAS siRNA and its precursor sequences provided by the present invention can efficiently inhibit the expression of the K-RAS gene, and in vivo experiments have shown that the K-RAS siRNA has a certain inhibitory effect on tumours highly expressing K-RAS. The precursor of the siRNA of the invention and its vector can form a stable siRNA that functions in a host.

公开(公告)号：US10155947B2

公开(公告)日：2018-12-18

申请号：US15507984

申请日：2015-09-01

Applicant: JIANGSU MICROMEDMARK BIOTECH CO., LTD.

Inventor： Chenyu Zhang ,  Hongwei Liang ,  Zhen Zhou ,  Ke Zeng ,  Xi Chen

IPC: C12N15/113 ,  A61K48/00 ,  A61K36/76 ,  A61K36/81 ,  A61K36/185 ,  A61K36/195 ,  A61K36/31 ,  A61K36/355 ,  A61K36/48

Abstract: Provided are a method and use of microRNA MiR-2911 in regulating an ebola virus. Particularly provided are a method and use of isolated microRNA MiR-2911 in regulating an ebola virus protein gene.