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公开(公告)号：US20170267646A1
公开(公告)日：2017-09-21
申请号：US15519886
申请日：2015-11-12
发明人： Wenzheng Liu , Guocheng Wang , Qingwei Hou , Qiaoping Cui , Zhanyuan Zhu , Jinping Liu , Mingbo Yang , Hongguang Meng
IPC分类号： C07D239/08 , C07D217/00 , A61K31/5395 , C07D401/04 , C07D239/22
CPC分类号： C07D239/08 , A61K31/5395 , C07D217/00 , C07D239/22 , C07D401/04
摘要： Provided is a preparation method for revaprazan hydrochloride, the method comprising: (1) the preparation of 4-hydroxyl-2-(4-fluoroaniline)-5,6-dimethylpyrimidine; (2) the preparation of 4-chloro-2-(4-fluoroaniline)-5,6-dimethylpyrimidine; (3) the preparation of revaprazan hydrochloride. The method has advantages such as simple operations, high product purity, good yield and suitability for industrial production.
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公开(公告)号：US09981917B2
公开(公告)日：2018-05-29
申请号：US15519886
申请日：2015-11-12
发明人： Wenzheng Liu , Guocheng Wang , Qingwei Hou , Qiaoping Cui , Zhanyuan Zhu , Jinping Liu , Mingbo Yang , Hongguang Meng
IPC分类号： C07D401/04 , C07D239/08 , C07D239/22 , A61K31/5395 , C07D217/00
CPC分类号： C07D239/08 , A61K31/5395 , C07D217/00 , C07D239/22 , C07D401/04
摘要： Provided is a preparation method for revaprazan hydrochloride, the method comprising: (1) the preparation of 4-hydroxyl-2-(4-fluoroaniline)-5,6-dimethylpyrimidine; (2) the preparation of 4-chloro-2-(4-fluoroaniline)-5,6-dimethylpyrimidine; (3) the preparation of revaprazan hydrochloride. The method has advantages such as simple operations, high product purity, good yield and suitability for industrial production.
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