公开(公告)号：US20170313718A1

公开(公告)日：2017-11-02

申请号：US15513854

申请日：2015-09-23

申请人： JIAQIANG CAI ,  ALEJANDRO CRESPO ,  JOHN DEBENHAM ,  XIAOXING DU ,  PING LIU ,  RONGQIANG LIU ,  CHRISTINA B. MADSEN-DUGGAN ,  WEIGUO QUAN ,  CHRISTOPHER SINZ ,  LIPING WANG

发明人： JIAQIANG CAI ,  ALEJANDRO CRESPO ,  JOHN DEBENHAM ,  XIAOXING DU ,  PING LIU ,  RONGQIANG LIU ,  CHRISTINA B. MADSEN-DUGGAN ,  WEIGUO QUAN ,  CHRISTOPHER SINZ ,  LIPING WANG

IPC分类号： C07D495/04 ,  C07D491/048

CPC分类号： C07D495/04 ,  A61P7/06 ,  C07D491/048

摘要： The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

公开(公告)号：US20170226120A1

公开(公告)日：2017-08-10

申请号：US15514537

申请日：2015-09-23

申请人： JIAQIANG CAI ,  ALEJANDRO CRESPO ,  XIAOXING DU ,  BYRON GABRIEL DUBOIS ,  PING LIU ,  RONGQIANG LIU ,  WEIGUO QUAN ,  CHRISTOPHER SINZ ,  LIPING WANG

发明人： JIAQIANG CAI ,  ALEJANDRO CRESPO ,  XIAOXING DU ,  BYRON GABRIEL DUBOIS ,  PING LIU ,  RONGQIANG LIU ,  WEIGUO QUAN ,  CHRISTOPHER SINZ ,  LIPING WANG

IPC分类号： C07D491/048

CPC分类号： C07D491/048 ,  A61P7/06 ,  A61P9/10

摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.