公开(公告)号：US20220144744A1

公开(公告)日：2022-05-12

申请号：US17433826

申请日：2019-06-11

申请人： JILIN ASYMCHEM LABORATORIES CO., LTD.

发明人： Hao Hong ,  Enxuan Zhang ,  Jiangping Lu ,  Fuliang Wei ,  Sihang Yang ,  Guanda Che

IPC分类号： C07C45/68 ,  B01J19/00 ,  B01J19/12

摘要： Provided is a continuous synthesis method for 1,1′-bicyclic[1.1.1]pentane-1,3-diethyl ketone compounds. The continuous synthesis method comprises: under the irradiation of a light source, continuously conveying raw material A and raw material B to a continuous reaction device for a continuous photochemical reaction to obtain 1,1′-bicyclic[1.1.1]pentane-1,3-diethyl ketone compounds, and controlling the reaction temperature in the continuous reaction device by a temperature control device during the continuous photochemical reaction. A propellane with substituents, as a reaction raw material, is subjected to the above photochemical reaction in the continuous reaction device to reduce the probability of its slow decomposition and deterioration under the irradiation, and greatly improve the conversion rate of the reaction material and product yield.

公开(公告)号：US12129228B2

公开(公告)日：2024-10-29

申请号：US17433826

申请日：2019-06-11

申请人： JILIN ASYMCHEM LABORATORIES CO., LTD.

发明人： Hao Hong ,  Enxuan Zhang ,  Jiangping Lu ,  Fuliang Wei ,  Sihang Yang ,  Guanda Che

IPC分类号： C07C45/68 ,  B01J19/00 ,  B01J19/12

CPC分类号： C07C45/68 ,  B01J19/0066 ,  B01J19/121 ,  B01J2219/00033 ,  C07C2602/38 ,  C07C45/68 ,  C07C49/323 ,  C07C45/68 ,  C07C49/35

摘要： Provided is a continuous synthesis method for 1,1′-bicyclic[1.1.1]pentane-1,3-diethyl ketone compounds. The continuous synthesis method comprises: under the irradiation of a light source, continuously conveying raw material A and raw material B to a continuous reaction device for a continuous photochemical reaction to obtain 1,1′-bicyclic[1.1.1]pentane-1,3-diethyl ketone compounds, and controlling the reaction temperature in the continuous reaction device by a temperature control device during the continuous photochemical reaction. A propellane with substituents, as a reaction raw material, is subjected to the above photochemical reaction in the continuous reaction device to reduce the probability of its slow decomposition and deterioration under the irradiation, and greatly improve the conversion rate of the reaction material and product yield.