公开(公告)号：US11447574B2

公开(公告)日：2022-09-20

申请号：US16564148

申请日：2019-09-09

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Andrey Borisovich Ulitin ,  Stanislav Rudolfovich Evdokimov ,  Valeriy Vladimirovich Soloviev ,  Yulia Sergeevna Chernykh ,  Olga Vladimirovna Goncharova ,  Dmitriy Valerievich Korzhavin ,  Tatyana Veniaminovna Chernovskaya ,  Timofey Aleksandrovich Nemankin ,  Roman Alexeevich Ivanov ,  Dmitriy Valentinovich Morozov ,  Victoria Mikhailovna Ekimova ,  Ekaterina Vladimirovna Sofronova ,  Yakov Yurevich Ustyugov

IPC: A61K39/395 ,  C07K16/46 ,  A61K45/06 ,  C07K16/24

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

公开(公告)号：US10442869B2

公开(公告)日：2019-10-15

申请号：US15254225

申请日：2016-09-01

Applicant: CLOSED JOINT STOCK COMPANY “BIOCAD”

Inventor： Andrey Borisovich Ulitin ,  Stanislav Rudolfovich Evdokimov ,  Valeriy Vladimirovich Soloviev ,  Yulia Sergeevna Chernyh ,  Olga Vladimirovna Goncharova ,  Dmitriy Valerievich Korzhavin ,  Tatyana Veniaminovna Chernovskaya ,  Timofey Aleksandrovich Nemankin ,  Roman Alexeevich Ivanov ,  Dmitriy Valentinovich Morozov ,  Victoria Mikhailovna Ekimova ,  Ekaterina Vladimirovna Sofronova ,  Yakov Yurevich Ustyugov

IPC: A61K39/395 ,  C07K16/46 ,  A61K45/06 ,  C07K16/24

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.