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    Method of inhibiting and inducing human platelet aggregation
    1.
    发明授权
    Method of inhibiting and inducing human platelet aggregation 失效
    抑制和诱导人血小板聚集的方法

    公开(公告)号：US4661471A

    公开(公告)日：1987-04-28

    申请号：US599477

    申请日：1984-04-10

    申请人： Jack J. Hawiger ,  Sheila Timmons ,  Thomas J. Lukas ,  Marek Kloczewiak

    发明人： Jack J. Hawiger ,  Sheila Timmons ,  Thomas J. Lukas ,  Marek Kloczewiak

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K14/75 ,  C07K19/00 ,  C07K7/08 ,  A61K37/02

    CPC分类号： C07K14/75 ,  C07K19/00 ,  A61K38/00

    摘要： A method of inhibiting thrombin or ADP-induced human platelet aggregation by fibrinogen has been developed. The administration of the small molecular weight peptide or the synthetic inhibitory molecule of the invention significantly inhibits thrombin or ADP-modified human platelets binding of fibrinogen, a plasma protein necessary for platelet aggregation. The method of the invention is useful for inhibiting of the formation of hemostatic platelet plugs and of the initiation of thrombotic lesions. The blockage caused by hemostatic platelet plugs and the damage caused by thrombotic lesions are major factors in heart disease and stroke. The invention also includes a method of inducing the formation of thrombin or ADP-modified platelet aggregates by administration of a synthetic aggregating molecule which represents a functional substitute for fibrinogen.

    摘要翻译： 已经开发了通过纤维蛋白原抑制凝血酶或ADP诱导的人血小板聚集的方法。 本发明的小分子量肽或合成抑制性分子的给药显着抑制凝血酶或ADP修饰的人血小板结合纤维蛋白原，血小板聚集所必需的血浆蛋白。 本发明的方法可用于抑制止血栓塞的形成和血栓形成病变的起始。 止血栓塞造成的堵塞以及由血栓形成病变引起的损伤是心脏病和中风的主要因素。 本发明还包括通过施用代表纤维蛋白原的功能性替代物的合成聚集分子诱导凝血酶或ADP改性的血小板聚集体形成的方法。