公开(公告)号：US20230094832A1

公开(公告)日：2023-03-30

申请号：US17796413

申请日：2021-01-27

申请人： Jae Hyung PARK ,  Jung Min SHIN ,  So Young SON

发明人： Jae Hyung PARK ,  Jung Min SHIN ,  So Young SON

IPC分类号： A61K47/68 ,  C07K16/28 ,  A61K47/65 ,  A61K31/513 ,  A61P35/00

摘要： The present invention relates to an antibody-drug conjugate comprising an exosome secretion inhibitor conjugated to an antibody for inhibiting immune checkpoints, and the use thereof for treating cancer. An antibody-drug conjugate according to the present invention is maintained, in normal tissue, in a form in which a drug is conjugated to an antibody, and releases the drug upon reaching a cancer microenvironment, thereby inhibiting the secretion of cancer exosomes that cause an immunosuppressive mechanism. Thus the antibody-drug conjugate exhibits high therapeutic efficacy and can remarkably increase the objective response rate to an immune checkpoint inhibitor.