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公开(公告)号：US08481502B2
公开(公告)日：2013-07-09
申请号：US13441696
申请日：2012-04-06
申请人： James Bradley Aggen , Paola Dozzo , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
发明人： James Bradley Aggen , Paola Dozzo , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q 1，Q 2，Q 5，R 1，R 2，R 3，Z 1和Z 2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US08318685B2
公开(公告)日：2012-11-27
申请号：US13295219
申请日：2011-11-14
申请人： Adam Aaron Goldblum , Paola Dozzo , Timothy Robert Kane , James Bradley Aggen , Martin Sheringham Linsell , Darin James Hildebrandt , Micah James Gliedt
发明人： Adam Aaron Goldblum , Paola Dozzo , Timothy Robert Kane , James Bradley Aggen , Martin Sheringham Linsell , Darin James Hildebrandt , Micah James Gliedt
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Q1 and Q2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中Q1和Q2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US20120258925A1
公开(公告)日：2012-10-11
申请号：US13441696
申请日：2012-04-06
申请人： James Bradley Aggen , Paola Dozzo , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
发明人： James Bradley Aggen , Paola Dozzo , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
IPC分类号： A61K31/7036 , A61P31/04 , C07H15/232
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q 1，Q 2，Q 5，R 1，R 2，R 3，Z 1和Z 2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US20120283208A1
公开(公告)日：2012-11-08
申请号：US13441699
申请日：2012-04-06
申请人： James Bradley Aggen , Adam Aaron Goldblum , Paola Dozzo , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
发明人： James Bradley Aggen , Adam Aaron Goldblum , Paola Dozzo , Darin James Hildebrandt , Timothy Robert Kane , Micah James Gliedt , Martin Sheringham Linsell
IPC分类号： A61K31/7036 , A61P31/04 , A61K31/7052 , A61K31/706 , C07H15/26 , C07H15/232
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 所述化合物具有以下结构（I）：其包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2，R3，Z1和Z2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US20120172332A1
公开(公告)日：2012-07-05
申请号：US13082143
申请日：2011-04-07
申请人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
发明人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
IPC分类号： A61K31/7008 , A61P31/04 , C07H5/06
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2和R3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US08367625B2
公开(公告)日：2013-02-05
申请号：US13082141
申请日：2011-04-07
申请人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
发明人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20110288041A1
公开(公告)日：2011-11-24
申请号：US13082141
申请日：2011-04-07
申请人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
发明人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Heinz Ernst Moser
IPC分类号： A61K31/7048 , A61P31/04 , C07H15/26
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2和R3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US20120122809A1
公开(公告)日：2012-05-17
申请号：US13295219
申请日：2011-11-14
申请人： Adam Aaron Goldblum , Paola Dozzo , Timothy Robert Kane , James Bradley Aggen , Martin Sheringham Linsell , Darin James Hildebrandt , Micah James Gliedt
发明人： Adam Aaron Goldblum , Paola Dozzo , Timothy Robert Kane , James Bradley Aggen , Martin Sheringham Linsell , Darin James Hildebrandt , Micah James Gliedt
IPC分类号： A61K31/7036 , A61P31/04 , C07H15/232
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Q1 and Q2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中Q1和Q2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US20110275586A1
公开(公告)日：2011-11-10
申请号：US13044234
申请日：2011-03-09
申请人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Stephen Hanessian , Alexandre Giguère , Justyna Grzyb , Juan Pablo Maianti
发明人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Stephen Hanessian , Alexandre Giguère , Justyna Grzyb , Juan Pablo Maianti
IPC分类号： A61K31/7036 , A61P31/04 , C07H15/232
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Z1, Z2, Z3, Z4, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q 1，Q 2，Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US08399419B2
公开(公告)日：2013-03-19
申请号：US13044234
申请日：2011-03-09
申请人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Stephen Hanessian , Alexandre Giguère , Justyna Grzyb , Juan Pablo Maianti
发明人： James Bradley Aggen , Martin Sheringham Linsell , Adam Aaron Goldblum , Darin James Hildebrandt , Timothy Robert Kane , Paola Dozzo , Micah James Gliedt , Stephen Hanessian , Alexandre Giguère , Justyna Grzyb , Juan Pablo Maianti
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Z1, Z2, Z3, Z4, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q 1，Q 2，Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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