公开(公告)号：US06706032B2

公开(公告)日：2004-03-16

申请号：US09878155

申请日：2001-06-07

申请人： James C. Weaver ,  R. Rox Anderson ,  Terry O Herndon ,  T. R. Gowrishankar ,  Elizabeth A. Gift ,  Salvador Gonzalez

发明人： James C. Weaver ,  R. Rox Anderson ,  Terry O Herndon ,  T. R. Gowrishankar ,  Elizabeth A. Gift ,  Salvador Gonzalez

IPC分类号： A61M3100

CPC分类号： A61N1/325 ,  A61M5/427 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/044 ,  A61N1/30

摘要： The present invention relates to methods and devices used for the formation of microconduits in a tissue. The term “microconduit” refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microconduit being formed upon impact of a plurality of accelerated microparticles with the surface of the tissue. A method is described for forming at least one microconduit in tissue including the steps of: accelerating a plurality of microparticles to a velocity that causes the microparticles to penetrate a region of tissue surface upon impingement of the microparticles on the tissue surface; and directing the microparticle towards the region of tissue surface, thereby causing the microparticles to penetrate the tissue and form a microconduit in the tissue. According to an embodiment, microparticles are accelerated by being hit with a moving, solid surface. In another embodiment, microparticles are accelerated by a flowing gas or liquid. Also described are methods and devices for using microconduits to deliver therapeutic molecules and ions into tissue, or for extraction of chemical analytes out of tissue. Also described is a method of nail piercing to accommodate jewelry.

摘要翻译： 本发明涉及用于在组织中形成微管的方法和装置。 术语“微管道”是指通过液体流动允许材料转移并通过电泳的组织中的或通过组织的小的开口，通道或孔，在多个加速的微粒撞击时形成的微管， 组织表面。 描述了一种用于在组织中形成至少一个微管的方法，包括以下步骤：将多个微粒加速到使微粒在组织表面上碰撞时穿透组织表面区域的速度; 并将微粒引向组织表面的区域，从而使微粒穿透组织并在组织中形成微管。 根据一个实施例，通过用移动的固体表面击打微粒被加速。 在另一个实施方案中，微粒被流动的气体或液体加速。 还描述了使用微管道将治疗分子和离子递送到组织中或从组织中提取化学分析物的方法和装置。 还描述了一种钉子穿孔以适应首饰的方法。