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1.发明授权Biologically active taxane analogs and methods of treatment by oral administration 有权生物活性紫杉烷类似物和口服治疗方法公开(公告)号：US08273789B2
公开(公告)日：2012-09-25
申请号：US12873477
申请日：2010-09-01
申请人： James D. McChesney , Gilles Tapolsky , David L. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
发明人： James D. McChesney , Gilles Tapolsky , David L. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
IPC分类号： A61K31/35 , A61K31/335 , C07D309/00 , C07D407/00
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译： 本发明涉及式S-（1）的新型化合物：用于治疗癌症的组合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。
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2.发明授权Biologically active taxane analogs and methods of treatment by oral administration 有权生物活性紫杉烷类似物和口服治疗方法公开(公告)号：US08552056B2
公开(公告)日：2013-10-08
申请号：US13620852
申请日：2012-09-15
申请人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
发明人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
IPC分类号： A61K31/335 , A61K31/44 , C07D407/00 , C07D309/00
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译： 本发明涉及式S-（1）的新型化合物：用于治疗癌症的组合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。
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公开(公告)号：US08409574B2
公开(公告)日：2013-04-02
申请号：US12859990
申请日：2010-08-20
申请人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
发明人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
IPC分类号： A61K39/00 , A61K31/415 , A61K31/335 , A01N43/52 , A01N43/32 , C07D309/00
CPC分类号： A61K31/357 , A61K31/337 , A61K31/4188 , A61K31/495 , A61K39/3955 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.
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4.发明申请Biologically Active Taxane Analogs and Methods of Treatment by Oral Administration 有权生物活性紫杉烷类似物和口服治疗方法公开(公告)号：US20140023699A1
公开(公告)日：2014-01-23
申请号：US13950316
申请日：2013-07-25
申请人： James D. McChesney , Gilles H. Tapolsky , David Lloyd Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel R. Modiano
发明人： James D. McChesney , Gilles H. Tapolsky , David Lloyd Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel R. Modiano
IPC分类号： C07D493/06 , A61K39/395 , A61K31/495 , A61K31/357 , A61K45/06
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译： 本发明涉及用于治疗癌症的新型化合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。
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