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公开(公告)号:US06525205B2
公开(公告)日:2003-02-25
申请号:US10117580
申请日:2002-04-05
IPC分类号: C07D30930
CPC分类号: C07D309/30
摘要: Crystalline 3-hydroxylactone-containing products can be prepared in high yield and purity in a one-pot process by treating the corresponding 3,5-dihydroxy acid with a strong mineral acid in a cold, aprotic, water-miscible solvent to effect lactonization, followed by addition of excess acid to effect crystallization of the lactonized product from the reaction mixture.
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公开(公告)号:US4956490A
公开(公告)日:1990-09-11
申请号:US321040
申请日:1989-03-09
申请人: James W. McManus , John F. Genus
发明人: James W. McManus , John F. Genus
IPC分类号: B01J31/12 , C07B61/00 , C07C51/09 , C07C51/347 , C07C51/36 , C07C59/84 , C07C59/90 , C07C205/56 , C07C253/30 , C07C255/57
CPC分类号: C07C51/347 , C07C51/36
摘要: There is disclosed a continuous, non-isolation process for preparing benzylpyruvic acids and benzylpyruvic esters. The benzylpyruvic acids and esters obtained are useful as intermediates to prepare carboxyalkyl dipeptide compounds which are used as angiotension converting enzyme (ACE) inhibitors to treat hypertension.
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