公开(公告)号：US4582055A

公开(公告)日：1986-04-15

申请号：US612776

申请日：1984-05-22

申请人： James N. McDougal ,  Michael L. Gargas ,  Robert A. Strohaver ,  Gary W. Jepson ,  Kenneth R. Thimling ,  Mark A. Williams

发明人： James N. McDougal ,  Michael L. Gargas ,  Robert A. Strohaver ,  Gary W. Jepson ,  Kenneth R. Thimling ,  Mark A. Williams

IPC分类号： A61D7/04 ,  A61M16/00

CPC分类号： A61D7/04

摘要： A method and system for in vivo dermal absorption testing of a laboratory animal uses a mask and harness for protecting the respiratory tract of the animal when the animal housed within a sealed chamber with a hazardous test vapor introduced in the chamber. Because of the difficulty of getting a good seal with a protective mask on a laboratory animal, this system is designed with an air leak from inside the mask into the chamber. To ensure that the test vapor does not infiltrate the mask nor leak from the chamber, the vapor is maintained at a negative pressure within the chamber as compared to the external atmospheric pressure and air is supplied to the mask for the animal to breathe at a positive pressure and at a greater rate than that needed by the animal.

摘要翻译： 实验室动物的体内皮肤吸收测试的方法和系统使用面罩和线束来保护动物的呼吸道，当动物被容纳在具有引入室内的危险测试蒸气的密封室中时。 由于在实验室动物上难以用防护面罩获得良好的密封，因此该系统设计为具有从面罩内部进入腔室的空气泄漏。 为了确保测试蒸汽不会渗透到面罩中，也不会从室泄漏，与外部大气压力相比，蒸气在室内保持在负压，空气被供给到面罩中，以使动物呼吸为阳性 压力和比动物需要的更大的速度。