公开(公告)号：US06534516B1

公开(公告)日：2003-03-18

申请号：US09448992

申请日：1999-11-24

申请人： James P Edwards ,  Robert Higuchi ,  Todd K Jones ,  Lawrence G Hamann

发明人： James P Edwards ,  Robert Higuchi ,  Todd K Jones ,  Lawrence G Hamann

IPC分类号： C07D48704

CPC分类号： C07D471/04 ,  C07D471/14

摘要： Non-steroidal compounds that are high affinity, high selectivity modulators for androgen receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring androgen receptor agonist, partial agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the androgen receptor modulator compounds.

摘要翻译： 公开了用于雄激素受体的高亲和力，高选择性调节剂的非甾体化合物。 还公开了掺入这种化合物的药物组合物，使用所公开的化合物的方法和用于治疗需要雄激素受体激动剂的患者的组合物，部分激动剂或拮抗剂治疗，可用于制备化合物的中间体和用于制备雄激素受体调节剂化合物的方法 。

公开(公告)号：US6017924A

公开(公告)日：2000-01-25

申请号：US373460

申请日：1999-08-12

申请人： James P Edwards ,  Robert Higuchi ,  Todd K Jones ,  Lawrence G Hamann

发明人： James P Edwards ,  Robert Higuchi ,  Todd K Jones ,  Lawrence G Hamann

IPC分类号： C07D471/04 ,  C07D471/14 ,  C07D498/16 ,  A61K31/44

CPC分类号： C07D471/04 ,  C07D471/14

摘要： Non-steroidal compounds that are high affinity, high selectivity modulators for androgen receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring androgen receptor agonist, partial agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the androgen receptor modulator compounds.