公开(公告)号：US20160175292A1

公开(公告)日：2016-06-23

申请号：US14978448

申请日：2015-12-22

Applicant: James Tour

Inventor： James Tour ,  Redwan Huq ,  Jason A. Mann ,  Almaz Jalilov ,  Lizanne Nilewski ,  Tom Kent ,  Christine Beeton

IPC: A61K31/4375

CPC classification number: A61K31/05 ,  A61K31/122 ,  A61K31/235 ,  A61K31/336 ,  A61K31/352 ,  A61K31/407 ,  A61K31/473 ,  A61K31/4745

Abstract: Disclosed is a method of treating diseases which are: reactive oxygen species mediated, ischemic or reperfusion-related, or T-cell mediated, including autoimmune diseases. The method is administering a therapeutically effective amount of a formulation wherein the active ingredient includes non-phenolic aromatic structures that are electron deficient and are capable of converting the superoxide radical to O2; and/or of converting superoxide radical to oxygen and hydrogen peroxide, or pharmaceutically acceptable salts of said structures. Also disclosed is a method of diagnosing and treating such diseases and conditions.

Abstract translation: 公开了一种治疗疾病的方法，所述疾病是：介导的活性氧，缺血或再灌注相关或T细胞介导的，包括自身免疫性疾病。 该方法是施用治疗有效量的制剂，其中活性成分包括电子缺乏并能够将超氧化物自由基转化为O 2的非酚类芳族结构; 和/或将超氧自由基转化为氧和过氧化氢，或所述结构的药学上可接受的盐。 还公开了诊断和治疗这些疾病和病症的方法。