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公开(公告)号：US07445772B2
公开(公告)日：2008-11-04
申请号：US11675890
申请日：2007-02-16
申请人： James W. West , Stacey Tannheimer
发明人： James W. West , Stacey Tannheimer
IPC分类号： A61K38/19
CPC分类号： C07K14/5434 , A61K38/00 , C12N15/62 , Y10S514/885
摘要： Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka IL-12A). The proteins may be produced as fusion proteins or expressed as a single chain. The heterdimeric protein comprising zsig81 and p19 is designated zcyto33f2 and the heterodimeric protein comprising zsig81 and p35 is designated zcyto35f2. Zcyto33f2 and zcyto35f2 proteins are associated with epithelial cell types, including lung and gut epithelium, and may play a role in physiological conditions such as inflammation.
摘要翻译： 公开了包含两个螺旋束细胞因子的异二聚体蛋白。 多肽中的一种包含zsig81和包含p19（又名IL-12A）或p35（又名IL-12A）的第二多肽。 蛋白质可以作为融合蛋白产生或表达为单链。 包含zsig81和p19的杂二聚体蛋白质被命名为zcyto33f2，包含zsig81和p35的异二聚体蛋白质被命名为zcyto35f2。 Zcyto33f2和zcyto35f2蛋白与上皮细胞类型（包括肺和肠上皮）相关，并且可能在诸如炎症的生理条件中起作用。
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公开(公告)号：US07196172B2
公开(公告)日：2007-03-27
申请号：US11486758
申请日：2006-07-14
申请人： James W. West , Stacey Tannheimer
发明人： James W. West , Stacey Tannheimer
CPC分类号： C07K14/5434 , A61K38/00 , C12N15/62 , Y10S514/885
摘要： Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka L-12A). The proteins may be produced as fusion proteins or expressed as a single chain. The heterdimeric protein comprising zsig81 and p19 is designated zcyto33f2 and the heterodimeric protein comprising zsig81 and p35 is designated zcyto35f2. Zcyto33f2 and zcyto35f2 proteins are associated with epithelial cell types, including lung and gut epithelium, and may play a role in physiological conditions such as inflammation.
摘要翻译： 公开了包含两个螺旋束细胞因子的异二聚体蛋白。 多肽中的一种包含zsig81和包含p19（也称为IL-12A）或p35（也称为L-12A）的第二多肽。 蛋白质可以作为融合蛋白产生或表达为单链。 包含zsig81和p19的杂二聚体蛋白质被命名为zcyto33f2，包含zsig81和p35的异二聚体蛋白质被命名为zcyto35f2。 Zcyto33f2和zcyto35f2蛋白与上皮细胞类型（包括肺和肠上皮）相关，并且可能在诸如炎症的生理条件中起作用。
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公开(公告)号：US20070014761A1
公开(公告)日：2007-01-18
申请号：US11486758
申请日：2006-07-14
申请人： James West , Stacey Tannheimer
发明人： James West , Stacey Tannheimer
CPC分类号： C07K14/5434 , A61K38/00 , C12N15/62 , Y10S514/885
摘要： Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka L-12A). The proteins may be produced as fusion proteins or expressed as a single chain. The heterdimeric protein comprising zsig81 and p19 is designated zcyto33f2 and the heterodimeric protein comprising zsig81 and p35 is designated zcyto35f2. Zcyto33f2 and zcyto35f2 proteins are associated with epithelial cell types, including lung and gut epithelium, and may play a role in physiological conditions such as inflammation.
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公开(公告)号：US20070167367A1
公开(公告)日：2007-07-19
申请号：US11675890
申请日：2007-02-16
申请人： James West , Stacey Tannheimer
发明人： James West , Stacey Tannheimer
IPC分类号： A61K38/17
CPC分类号： C07K14/5434 , A61K38/00 , C12N15/62 , Y10S514/885
摘要： Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka IL-12A). The proteins may be produced as fusion proteins or expressed as a single chain. The heterdimeric protein comprising zsig81 and p19 is designated zcyto33f2 and the heterodimeric protein comprising zsig81 and p35 is designated zcyto35f2. Zcyto33f2 and zcyto35f2 proteins are associated with epithelial cell types, including lung and gut epithelium, and may play a role in physiological conditions such as inflammation.
摘要翻译： 公开了包含两个螺旋束细胞因子的异二聚体蛋白。 多肽中的一种包含zsig81和包含p19（又名IL-12A）或p35（又名IL-12A）的第二多肽。 蛋白质可以作为融合蛋白产生或表达为单链。 包含zsig81和p19的杂二聚体蛋白质被命名为zcyto33f2，包含zsig81和p35的异二聚体蛋白质被命名为zcyto35f2。 Zcyto33f2和zcyto35f2蛋白与上皮细胞类型（包括肺和肠上皮）相关，并且可能在诸如炎症的生理条件中起作用。
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