专利检索 ap:("Jan JOHANSSON" OR "Göran HJÄLM" OR "Margareta Stark" OR "Anna Rising" OR "Stefan Grip" OR "Wilhelm Engström" OR "My Hedhammar") AND inv:"Göran HJÄLM" 第 1 页

1.

发明申请
SPIDER SILK PROTEINS AND METHODS FOR PRODUCING SPIDER SILK PROTEINS 有权

公开(公告)号：US20120329992A1

公开(公告)日：2012-12-27

申请号：US13598119

申请日：2012-08-29

申请人： Jan JOHANSSON , Göran HJÄLM , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar

发明人： Jan JOHANSSON , Göran HJÄLM , Margareta Stark , Anna Rising , Stefan Grip , Wilhelm Engström , My Hedhammar

IPC分类号： C07K14/435 , C12P21/02 , C12N15/62 , C07K19/00 , C12N15/12

CPC分类号： C07K14/43518 , A61K35/12 , A61K47/42 , D01F4/00

摘要： The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.