公开(公告)号：US20060228432A1

公开(公告)日：2006-10-12

申请号：US11449733

申请日：2006-06-09

申请人： Janaswamy Rao ,  Pullela Srinivas ,  Vummenthala Anuradha ,  Ashok Tiwari ,  Amtul Ali ,  Jhillu Yadav ,  Kondapuram Raghavan

发明人： Janaswamy Rao ,  Pullela Srinivas ,  Vummenthala Anuradha ,  Ashok Tiwari ,  Amtul Ali ,  Jhillu Yadav ,  Kondapuram Raghavan

IPC分类号： A61K36/67 ,  A61K31/36

CPC分类号： A61K31/36 ,  A61K31/164 ,  A61K36/67

摘要： The present invention relates to a method for providing α-glucosidase inhibition to a subject by administering a pharmaceutical composition comprising a α-glucosidase inhibitory agent selected from pipataline (formula 1a), sesamin (formula 1b), pellitorine (Formula 1c), guineensine (Formula 1d) and brachystamide-B (formula 1e) having therapeutic application for diabetes mellitus, cancer, viral diseases such as hepatitis B and C, HIV, AIDS etc; also the invention provides a process for the isolation of said α-glucosidase inhibitory agent from the plant source Piper longum in significant yields.

摘要翻译： 本发明涉及一种通过给药药物组合物提供α-葡糖苷酶抑制作用的方法，所述药物组合物包含选自哌啶aline啶（式1a），芝麻素（式1b），扑地酮（通式1c），吉尼赛因 具有治疗性应用于糖尿病，癌症，乙型和丙型肝炎病毒性疾病，艾滋病毒，艾滋病等病毒性疾病的方案1d）和brachystamide-B（式1e）; 本发明还提供了以显着产率从植物来源Pi子中分离所述α-葡糖苷酶抑制剂的方法。

公开(公告)号：US20050089583A1

公开(公告)日：2005-04-28

申请号：US10695471

申请日：2003-10-28

申请人： Janaswamy Rao ,  Upparapalli Sampathkumar ,  Boggavarapu Sastry ,  Jhillu Yadav ,  Kondapuram Raghavan ,  Gautam Palit ,  Dwaraka Bhalla ,  Deepak Rai ,  Panniyampally Varier ,  Trikovil Muraleedharan ,  Kollath Muraleedharan

发明人： Janaswamy Rao ,  Upparapalli Sampathkumar ,  Boggavarapu Sastry ,  Jhillu Yadav ,  Kondapuram Raghavan ,  Gautam Palit ,  Dwaraka Bhalla ,  Deepak Rai ,  Panniyampally Varier ,  Trikovil Muraleedharan ,  Kollath Muraleedharan

IPC分类号： A61K36/00 ,  A61K36/61 ,  A61K36/886 ,  A61K35/78

CPC分类号： A61K36/61 ,  A61K36/752 ,  Y10S514/924 ,  A61K2300/00

摘要： The present invention provides a synergistic herbal composition for the treatment of gastric ulcer, said composition essentially comprising of powdered plant parts of Asperagus racemosus, Glycyrrhiza glabra, Seaamum indicum, Musa sapientum and Trachyaparmum roxburghicinum and optionally, powdered plant parts of Cyclea peltate, Embelia ribes, Coriandrum sativum Ferula asafoetida, Aloe barbadensis and Evolvulus aisinodes along with one or more pharmaceutically acceptable additives/carriers, a process for preparing said composition and method for treating gastric ulcer using said composition.

摘要翻译： 本发明提供了用于治疗胃溃疡的协同草药组合物，所述组合物基本上包含粉状植物部分的Asperagus racemosus，Glycyrrhiza glabra，Seaamum indicum，Musa sapientum和Trachyaparmum roxburghicinum，以及任选的，Cyclea peltate，Embelia ribes ，Coriandrum sativum Ferula asafoetida，芦荟和Evolvulus aisinode以及一种或多种药学上可接受的添加剂/载体，制备所述组合物的方法和使用所述组合物治疗胃溃疡的方法。

公开(公告)号：US20080009544A1

公开(公告)日：2008-01-10

申请号：US11688359

申请日：2007-03-20

申请人： Janaswamy Rao ,  Bhimapaka Raju ,  Pullela Srinivas ,  Katragadda Babu ,  Jhillu Yadav ,  Kondapuram Raghvan ,  Hemant Singh ,  Chandiswar Nath

发明人： Janaswamy Rao ,  Bhimapaka Raju ,  Pullela Srinivas ,  Katragadda Babu ,  Jhillu Yadav ,  Kondapuram Raghvan ,  Hemant Singh ,  Chandiswar Nath

IPC分类号： A61K31/353 ,  A61P25/28

CPC分类号： A61K31/37

摘要： A pharmaceutical composition useful as acetylcholinesterase inhibitors. The present invention relates to pharmaceutical composition comprising the naturally occurring compounds selected from (±) Marmesin, Columbianetin, Dihydroxanthyletin and substituted coumarin derivatives of 7-allyloxy coumarin, 7-benzyloxy coumarin, 7-methoxy coumarin, 7-acetyloxy coumarin, 4-methyl-7-hydroxy coumarin and 4-methyl-7-acetyloxy coumarin. The said compositions posses a high degree of acetylcholinesterase inhibitory (AChE) property.

摘要翻译： 用作乙酰胆碱酯酶抑制剂的药物组合物。 本发明涉及包含天然存在的化合物的药物组合物，所述化合物选自（±）马尔西辛，哥伦比亚甜素，二羟基黄酮和7-烯丙氧基香豆素的取代香豆素衍生物，7-苄氧基香豆素，7-甲氧基香豆素，7-乙酰氧基香豆素，4-甲基 -7-羟基香豆素和4-甲基-7-乙酰氧基香豆素。 所述组合物具有高度的乙酰胆碱酯酶抑制（AChE）特性。

公开(公告)号：US20070213281A1

公开(公告)日：2007-09-13

申请号：US11651106

申请日：2007-01-09

申请人： Janaswamy Rao ,  Suresh Katragadda ,  Hari Tatipaka ,  Manjulatha Khanapur ,  Muralidhar Purohit ,  Venkata Pullela ,  Jhillu Yadav

发明人： Janaswamy Rao ,  Suresh Katragadda ,  Hari Tatipaka ,  Manjulatha Khanapur ,  Muralidhar Purohit ,  Venkata Pullela ,  Jhillu Yadav

IPC分类号： A61K31/7048 ,  A61K31/353

CPC分类号： A61K31/353 ,  A61K31/7048

摘要： The present invention relates to identification of Oroxylum indicum, Indian medicinal plant as a rich source for flavanoid compounds. Mucoprotective and antigastric ulcer properties in the flavone class of compounds isolated therefrom have been identified along with a flavanoids mixture in substantial yields from hexane and acetone extracts. The hexane extract was fractionated, purified and the compounds identified as Oroxylin A, Chrysin and Baicalein. The acetone extract was purified and the compounds obtained identified as methoxy chrysin, Oroxyloside methyl ester and chrysin-7-O-methyl glycoside.

摘要翻译： 本发明涉及鉴定作为黄烷类化合物的丰富来源的印度药用植物油桐。 从其分离的黄酮类化合物中的粘液保护和抗胃溃疡特性已经与来自己烷和丙酮提取物的大量产量的黄酮类混合物一起鉴定。 将己烷萃取液分馏，纯化，鉴定为Oroxylin A，Chrysin和Baicalein。 纯化丙酮提取物，得到的化合物为甲氧基氯霉素，Oxyxyloside甲酯和chrysin-7-O-甲基糖苷。

公开(公告)号：US20070123708A1

公开(公告)日：2007-05-31

申请号：US11368279

申请日：2006-03-03

申请人： Sree Rama Madugula ,  Swamy Thallapelly ,  Jyothirmai Bandarupally ,  Jhillu Yadav

发明人： Sree Rama Madugula ,  Swamy Thallapelly ,  Jyothirmai Bandarupally ,  Jhillu Yadav

IPC分类号： C07D215/38 ,  C07D215/04

CPC分类号： C07D215/18 ,  C07D215/04 ,  C07D215/20 ,  C07D215/26

摘要： The present invention provides an improved process for the synthesis of quinoline derivatives. More particularly the present invention provides an improved and economical process for the synthesis of quinoline derivatives by the reaction of aniline/substituted anilines using two different catalysts, ferric chloride and zinc chloride in a one-pot set up reaction.

摘要翻译： 本发明提供了合成喹啉衍生物的改进方法。 更具体地，本发明提供了通过在一锅式反应中使用两种不同催化剂，氯化铁和氯化锌的苯胺/取代的苯胺的反应来合成喹啉衍生物的改进和经济的方法。

公开(公告)号：US20050222168A1

公开(公告)日：2005-10-06

申请号：US10814777

申请日：2004-03-30

申请人： Yenamandra Venkateswarlu ,  Kodela Ravinder ,  Jhillu Yadav ,  Yandrapu Sarathkumar ,  Sistla Ramakrishna ,  Prakash Diwan ,  Janapala Rao ,  Ratnam Ramesh ,  Hartmut Laatsch

发明人： Yenamandra Venkateswarlu ,  Kodela Ravinder ,  Jhillu Yadav ,  Yandrapu Sarathkumar ,  Sistla Ramakrishna ,  Prakash Diwan ,  Janapala Rao ,  Ratnam Ramesh ,  Hartmut Laatsch

IPC分类号： A61K31/4745 ,  A61K31/496 ,  C07D471/02 ,  C07D471/04

CPC分类号： C07D471/04

摘要： A novel β-carboline guanidine derivative tiruchenduramine (1) and its derivatives are disclosed. These compounds have been isolated from the Indian ascidian Synoicum macroglossum. These compounds are useful in the treatment of diabetic disorder by providing inhibition of α (alpha)glucosidase.

摘要翻译： 公开了一种新的β-咔啉胍衍生物噻菌灵多胺（1）及其衍生物。 这些化合物已经从印度的腹泻大鼠中分离出来。 通过提供α（α）葡糖苷酶的抑制，这些化合物可用于治疗糖尿病。