公开(公告)号：US20190234935A1

公开(公告)日：2019-08-01

申请号：US16341074

申请日：2017-10-11

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Stephen Beck ,  Jose Antonio Chavez ,  Chen-Ni Chin ,  Thai Dinh ,  Jennifer Furman ,  Matt Husovsky ,  Xiefan Lin-Schmidt ,  Shannon Mullican ,  Shamina Rangwala ,  Vicki South

IPC: G01N33/50 ,  A61K49/00

CPC classification number: G01N33/502 ,  A61K49/0008 ,  C12Q1/6883 ,  G01N2333/495

Abstract: A novel receptor for GDF15 was identified (GFRAL), as well as the use of this receptor in the identification or screening of GDF15 agonists or antagonists. These agonist or antagonist compounds may be used to either potentiate or suppress GDF15-like effects, respectively, at the cellular and organism levels, and may be used in treatment of metabolic diseases, including obesity, type 2 diabetes, hyperglycemia, hyperinsulinemia, dyslipidemia, diabetic nephropathy, or anorexia.