公开(公告)号：US20240166720A1

公开(公告)日：2024-05-23

申请号：US18549795

申请日：2022-03-11

Applicant: Janssen Biotech, Inc.

Inventor： Ninkka TAMOT ,  Paul B. HARVILLA ,  Douglas YAMADA ,  Manuel Alejandro SEPULVEDA ,  Rajkumar GANESAN ,  Sanjaya SINGH

IPC: C07K14/705 ,  A61K39/00 ,  A61K39/39 ,  A61P37/04

CPC classification number: C07K14/70575 ,  A61K39/39 ,  A61P37/04 ,  A61K2039/55516 ,  C07K2319/00 ,  C07K2319/30

Abstract: Provided herein are bioengineered immunomodulatory fusion proteins and uses thereof for modulating immune responses, as well as uses for improving a response of a subject to a vaccine, or uses for treating a disease or disorder, such as cancer or a pathogen infection. Provided herein is a single chain trimeric CD40L Fc fusion protein comprising (a) three CD40 ligand CD40L subunits covalently linked to one another by peptide linkers (CD40L trimer); and (b) an Fc monomer peptide.