公开(公告)号：US20200095315A1

公开(公告)日：2020-03-26

申请号：US16580509

申请日：2019-09-24

Applicant: Janssen Biotech, Inc.

Inventor： Jewel Johans ,  Katherine Li ,  Colleen Marano ,  Richard Strauss ,  Hongyan Zhang ,  Christopher O'Brien ,  Omoniyi Adedokun ,  Kimberly Shields-Tuttle

IPC: C07K16/24 ,  A61K9/08 ,  A61K47/22 ,  A61K47/26 ,  A61K47/18 ,  A61K9/00 ,  A61P1/04

Abstract: Described are methods and compositions for clinical proven safe and effective treatment of ulcerative colitis, particularly moderately to severely active ulcerative colitis in patients who have had an inadequate response to or are intolerant of a conventional or existing therapy by intravenous and/or subcutaneous administration of an anti-IL-12/IL-23p40 antibody.