公开(公告)号：US20230014092A1

公开(公告)日：2023-01-19

申请号：US17757199

申请日：2020-12-11

Applicant: Janssen Biotech, Inc.

Inventor： Ernesto MUNOZ ,  Julianty ANGSANA ,  Carl MANTHEY ,  Xuejun LIU

IPC: G01N33/50

Abstract: A method of identifying a subject who is likely to be responsive to a treatment comprising an inhibitor of IL1α, or predicting the responsiveness of a subject to a treatment comprising an inhibitor of IL1α, comprising providing a sample from a subject; administering the inhibitor of IL1α to the sample; measuring levels of one or more biomarkers in the sample; and determining the pharmacodynamic or the pharmacokinetic effect of the inhibitor of IL1α based on the levels of the one or more biomarkers.

公开(公告)号：US20230003719A1

公开(公告)日：2023-01-05

申请号：US17757201

申请日：2020-12-11

Applicant: Janssen Biotech, Inc.

Inventor： Ernesto MUNOZ ,  Julianty ANGSANA ,  Carl MANTHEY ,  Xuejun LIU

IPC: G01N33/50 ,  G01N33/53 ,  G01N33/68

Abstract: A method of determining a pharmacodynamics or pharmacokinetic effect of an inhibitor of IL 1α comprising providing a sample from a subject; administering the inhibitor of IL 1α to the sample; measuring levels of one or more biomarkers in the sample; and determining the pharmacodynamic or the pharmacokinetic effect of the inhibitor of IL 1α based on the levels of the one or more biomarkers.