公开(公告)号：US20250099635A1

公开(公告)日：2025-03-27

申请号：US18832652

申请日：2023-01-25

Applicant: Janssen Biotech, Inc.

Inventor： Fei SHEN ,  Theresa MCDEVITT ,  Shalom GOLDBERG ,  Kristen WILLEY ,  Ryan M. SMITH ,  Sathyadevi VENKATARAMANI

IPC: A61K51/10

Abstract: Provided herein are immunoconjugates, such as radioimmunoconjugates, comprising a therapeutic moiety conjugated to an antibody or antigen binding domain with binding specificity for hK2. In certain embodiments, the hK2-specific immunoconjugate demonstrates a short half-life. Also provided herein are methods of using the immunoconjugates for selectively targeting cancer cells and for treating diseases such as prostate cancer.