公开(公告)号：US20230295292A1

公开(公告)日：2023-09-21

申请号：US18052172

申请日：2022-11-02

Applicant: Janssen Biotech, Inc.

Inventor： Jenna Goldberg ,  Shun Xin Wang Lin ,  Thomas J. Prior ,  Raluca Verona ,  Brendan Weiss

IPC: C07K16/28 ,  A61P35/00 ,  A61K31/454 ,  A61K31/573 ,  A61K39/395

CPC classification number: C07K16/28 ,  A61K31/454 ,  A61K31/573 ,  A61K39/3955 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2896 ,  A61K2039/545 ,  C07K2317/31

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics. In particular, methods are disclosed of using a GPRC5DxCD3 bispecific antibody, an anti-CD38 antibody and/or pomalidomide to treat cancers.