公开(公告)号：US20150158875A1

公开(公告)日：2015-06-11

申请号：US14623671

申请日：2015-02-17

申请人： Janssen Pharmaceutica NV

发明人： Mark R. Player ,  Raul Calvo ,  Jinsheng Chen ,  Sanath Meegalla ,  Daniel J. Parks ,  William J. Parsons ,  Scott Ballentine ,  Shawn Branum

IPC分类号： C07D487/04 ,  C07D473/00 ,  C07D471/04

CPC分类号： C07D471/04 ,  C07B2200/13 ,  C07C53/18 ,  C07C309/04 ,  C07D473/00 ,  C07D487/04

摘要： The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

摘要翻译： 本发明涉及取代的氮杂 - 双环咪唑衍生物，含有它们的药物组合物及其用于治疗由TRP M8调节的病症和状况的用途，包括例如炎症性疼痛，炎性痛觉过敏，炎症性超敏反应性病症，神经性疼痛，神经性 冷异常性疼痛，炎性体痛痛觉过敏，炎性内脏痛觉过敏，由寒冷和肺部疾病加重的心血管疾病加重。

公开(公告)号：US09409915B2

公开(公告)日：2016-08-09

申请号：US14623671

申请日：2015-02-17

申请人： Janssen Pharmaceutica NV

发明人： Mark R. Player ,  Raul Calvo ,  Jinsheng Chen ,  Sanath Meegalla ,  Daniel J. Parks ,  William J. Parsons ,  Scott Ballentine ,  Shawn Branum

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/5377 ,  A61K31/437 ,  A61K31/52 ,  A61K31/4985 ,  C07D473/00

CPC分类号： C07D471/04 ,  C07B2200/13 ,  C07C53/18 ,  C07C309/04 ,  C07D473/00 ,  C07D487/04

摘要： The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

摘要翻译： 本发明涉及取代的氮杂 - 双环咪唑衍生物，含有它们的药物组合物及其用于治疗由TRP M8调节的病症和状况的用途，包括例如炎症性疼痛，炎性痛觉过敏，炎症性超敏反应性病症，神经性疼痛，神经性 冷异常性疼痛，炎性体痛痛觉过敏，炎性内脏痛觉过敏，由寒冷和肺部疾病加重的心血管疾病加重。

公开(公告)号：US20160304518A1

公开(公告)日：2016-10-20

申请号：US15196262

申请日：2016-06-29

申请人： Janssen Pharmaceutica NV

发明人： Mark R. Player ,  Raul Calvo ,  Jinsheng Chen ,  Sanath Meegalla ,  Daniel J. Parks ,  William J. Parsons ,  Scott Ballentine ,  Shawn Branum

IPC分类号： C07D471/04 ,  C07C53/18 ,  C07C309/04 ,  C07D473/00 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07B2200/13 ,  C07C53/18 ,  C07C309/04 ,  C07D473/00 ,  C07D487/04

摘要： The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

公开(公告)号：US09718820B2

公开(公告)日：2017-08-01

申请号：US15196262

申请日：2016-06-29

申请人： Janssen Pharmaceutica NV

发明人： Mark R. Player ,  Raul Calvo ,  Jinsheng Chen ,  Sanath Meegalla ,  Daniel J. Parks ,  William J. Parsons ,  Scott Ballentine ,  Shawn Branum

IPC分类号： A61K31/5377 ,  A61K31/437 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07C53/18 ,  C07C309/04

CPC分类号： C07D471/04 ,  C07B2200/13 ,  C07C53/18 ,  C07C309/04 ,  C07D473/00 ,  C07D487/04

摘要： The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.