公开(公告)号：US20220105076A1

公开(公告)日：2022-04-07

申请号：US17423598

申请日：2020-01-15

Applicant: Japan Science and Technology Agency

Inventor： Takeshi Murata ,  Kouki Shimizu ,  Fabiana Lica Yakushiji ,  Katsuhiko Moriyama

IPC: A61K31/4184 ,  C12Q1/18 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/515 ,  A61P31/04

Abstract: An inhibitor for Na+-translocating V-ATPase activity including a compound represented by where R1 represents a group selected from a hydroxy group, an alkoxy group, and a haloalkoxy group, each bonded to an adjacent phenyl group via oxygen, or a group selected from a dialkylamino group, a heterocyclic amine, and a carboxylic acid amide group, each bonded to an adjacent phenyl group via nitrogen, or represents bromine, iodine, or a straight-chain hydrocarbon group. R2 represents hydrogen or a haloalkoxy group. Z1 represents an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aromatic hydrocarbon group, or a heterocyclic group, each optionally having an arbitrary substituent and having a structure containing a double bond selected from between the group and an adjacent phenyl group. The symbol * represents a bond to the adjacent phenyl group.