公开(公告)号：US20150064203A1

公开(公告)日：2015-03-05

申请号：US14383118

申请日：2013-03-05

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Taizo Uda ,  Emi Hifumi

IPC: C07K16/18

CPC classification number: C07K16/3023 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/515 ,  C07K2317/60 ,  C07K2317/73

Abstract: According to the present invention, an anticancer agent is provided that has as an active ingredient thereof a human antibody light chain that demonstrates cytotoxicity against cancer cells and particularly lung cancer cells. The anticancer agent of the present invention primarily comprises: a human antibody κ-type light chain in the form of a dimer in which the variable region is composed of a polypeptide represented by the amino acid sequence of SEQ ID NO: 1, 9 or 13 or an amino acid sequence in which one or a plurality of amino acids have been added, deleted or substituted in these amino acid sequences; or, a human antibody κ-type light chain in the form of a monomer in which the variable region is composed of a polypeptide represented by the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence in which one or a plurality of amino acids have been added, deleted or substituted in the amino acid sequence.

Abstract translation: 根据本发明，提供抗癌剂，其具有作为其活性成分的人抗体轻链，其对癌细胞特别是肺癌细胞具有细胞毒性。 本发明的抗癌剂主要包括：二聚体形式的人抗体和kgr-型轻链，其中可变区由SEQ ID NO：1,9或9的氨基酸序列表示的多肽组成; 13或其中在这些氨基酸序列中添加，缺失或取代一个或多个氨基酸的氨基酸序列; 或其单体形式的人抗体和kgr-型轻链，其中可变区由SEQ ID NO：19的氨基酸序列表示的多肽或其中一个或多个氨基酸序列 的氨基酸已经在氨基酸序列中加入，缺失或取代。

公开(公告)号：US10040863B2

公开(公告)日：2018-08-07

申请号：US15166647

申请日：2016-05-27

Applicant: Japan Science and Technology Agency

Inventor： Taizo Uda ,  Emi Hifumi

IPC: C07K16/30 ,  C07K16/18 ,  A61K39/00

Abstract: According to the present invention, an anticancer agent is provided that has as an active ingredient thereof a human antibody light chain that demonstrates cytotoxicity against cancer cells and particularly lung cancer cells. The anticancer agent of the present invention primarily comprises: a human antibody κ-type light chain in the form of a dimer in which the variable region is composed of a polypeptide represented by the amino acid sequence of SEQ ID NO: 1, 9 or 13 or an amino acid sequence in which one or a plurality of amino acids have been added, deleted or substituted in these amino acid sequences; or, a human antibody κ-type light chain in the form of a monomer in which the variable region is composed of a polypeptide represented by the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence in which one or a plurality of amino acids have been added, deleted or substituted in the amino acid sequence.