公开(公告)号：US08835456B1

公开(公告)日：2014-09-16

申请号：US13423935

申请日：2012-03-19

申请人： Jason Allan Wiles ,  Venkat Gadhachanada ,  Avinash Phadke ,  Milind Deshpande ,  Dawei Chen

发明人： Jason Allan Wiles ,  Venkat Gadhachanada ,  Avinash Phadke ,  Milind Deshpande ,  Dawei Chen

IPC分类号： A61K31/44 ,  C07D451/02

CPC分类号： C07D471/08 ,  A61K45/06

摘要： The invention provides compounds of Formula I and the pharmaceutically salts thereof. These compounds may be generally described as bridged-bicyclo indole-containing compounds. The variables shown in Formula I are defined herein. Certain compounds of Formula I are useful as antiviral agents. Compounds as disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compounds of Formula I and at least one pharmaceutically acceptable carrier. Such pharmaceutical compositions may contain a compound of Formula I as the only active agent or may contain a combination of a compound of Formula I and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in patients.

摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 这些化合物通常可以被描述为含桥连双环吲哚的化合物。 式I中所示的变量在本文中定义。 某些式I化合物可用作抗病毒剂。 本文公开的化合物是病毒复制的有效和/或选择性抑制剂，特别是丙型肝炎病毒复制。 本发明还提供含有一种或多种式I化合物和至少一种药学上可接受的载体的药物组合物。 这样的药物组合物可以含有式I化合物作为唯一的活性剂，或者可以含有式I化合物与一种或多种其它药物活性剂的组合。 本发明还提供了用于治疗患者中的病毒感染（包括丙型肝炎感染）的方法。