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公开(公告)号：US20130096115A1
公开(公告)日：2013-04-18
申请号：US13519299
申请日：2010-12-21
IPC分类号： C07D471/04 , C07D401/04 , C07D413/14 , C07D401/14
CPC分类号： C07D471/04 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/14 , A61K2300/00
摘要： Provided herein are PAK inhibitors. Also provided herein are compositions and methods for treating an individual suffering from autism.
摘要翻译： 本文提供PAK抑制剂。 本文还提供了治疗患有自闭症的个体的组合物和方法。
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公开(公告)号：US20130059824A1
公开(公告)日：2013-03-07
申请号：US13511608
申请日：2010-11-23
IPC分类号： A61K31/519 , A61P39/06 , A61K31/65 , A61P25/00 , A61K31/5377 , A61K31/506
CPC分类号： A61K31/497 , A61K31/13 , A61K31/519 , A61K31/65 , A61K45/06 , A61K2300/00
摘要： Provided herein are PAK inhibitors. Also provided herein are compositions and methods for treating an individual suffering from Mild Cognitive Impairment.
摘要翻译： 本文提供PAK抑制剂。 本文还提供了治疗轻度认知障碍患者的组合物和方法。
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公开(公告)号：US20120270844A1
公开(公告)日：2012-10-25
申请号：US13500293
申请日：2010-10-08
IPC分类号： A61K31/519 , G01N33/50 , A61K31/5377 , A61K31/506 , A61K31/65 , A61P25/28
CPC分类号： A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/52
摘要： Provided herein arc PAK inhibitors. Also provided herein are compositions and methods for treating an individual suffering from Alzheimer's disease.
摘要翻译： 弧形PAK抑制剂。 本文还提供了治疗患有阿尔茨海默病的个体的组合物和方法。
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公开(公告)号：US20120184547A1
公开(公告)日：2012-07-19
申请号：US13383740
申请日：2010-07-16
IPC分类号： A61K31/519 , A61P25/18 , A61P25/00 , A61K31/5377 , A61K31/506
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/006 , A61K9/0078 , A61K9/06 , A61K9/2054 , A61K9/4866 , A61K31/00 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5375
摘要： Provided herein are PAK inhibitors. Also provided herein are compositions and methods for treating an individual suffering from schizophrenia.
摘要翻译： 本文提供PAK抑制剂。 本文还提供了用于治疗患有精神分裂症的个体的组合物和方法。
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5.发明申请公开(公告)号：US20110319375A1
公开(公告)日：2011-12-29
申请号：US13190330
申请日：2011-07-25
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
IPC分类号： A61K31/573 , A61P27/16
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
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6.发明申请公开(公告)号：US20110319373A1
公开(公告)日：2011-12-29
申请号：US13190323
申请日：2011-07-25
申请人： Jay Lichter , Benedikt Vollrath , Andrew M. Trammel , Sergio G. Durón , Fabrice Piu , Luis A. Dellamary , Qiang Ye , Carl Lebel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Andrew M. Trammel , Sergio G. Durón , Fabrice Piu , Luis A. Dellamary , Qiang Ye , Carl Lebel , Michael Christopher Scaife , Jeffrey P. Harris
IPC分类号： A61K31/573 , A61P27/16
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
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7.发明授权Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders 有权受控释放的听觉压力调节剂组合物和治疗OTIC疾病的方法公开(公告)号：US08846770B2
公开(公告)日：2014-09-30
申请号：US12486697
申请日：2009-06-17
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
IPC分类号： A61K47/30 , A61K9/14 , A61K31/724
CPC分类号： A61K47/34 , A61K9/14 , A61K31/5377 , A61K31/5517 , A61K31/724
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是用于治疗耳科疾病或病症的组合物和方法，所述耳科疾病或病症具有耳神经压力调节剂组合物和通过直接将这些组合物和制剂直接施用于或经由灌注到目标物中而局部施用于患有耳科疾病或病症的个体的制剂 耳结构。
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8.发明授权公开(公告)号：US08680082B2
公开(公告)日：2014-03-25
申请号：US13190323
申请日：2011-07-25
申请人： Jay Lichter , Benedikt Vollrath , Andrew M. Trammel , Sergio G. Durón , Fabrice Piu , Luis A. Dellamary , Qiang Ye , Carl Lebel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Andrew M. Trammel , Sergio G. Durón , Fabrice Piu , Luis A. Dellamary , Qiang Ye , Carl Lebel , Michael Christopher Scaife , Jeffrey P. Harris
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
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9.发明申请Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders 有权控制释放的皮质类固醇组合物和治疗眼病的方法公开(公告)号：US20110319377A1
公开(公告)日：2011-12-29
申请号：US13190329
申请日：2011-07-25
申请人： Jay Lichter , Benedikt Vollrath , Andrew M. Trammel , Sergio G. Durón , Fabrice Piu , Luis A. Dellamary , Qiang Ye , Carl Lebel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Andrew M. Trammel , Sergio G. Durón , Fabrice Piu , Luis A. Dellamary , Qiang Ye , Carl Lebel , Michael Christopher Scaife , Jeffrey P. Harris
IPC分类号： A61K31/573 , A61P27/16 , A61P29/00 , A61P37/06
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了用类固醇，NSAID和/或腺苷三磷酸酶（“ATPase”）调节剂治疗耳部疾病的组合物和方法。 在这些方法中，通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中，将甾体，NSAID和/或ATP酶组合物和制剂局部施用于患有耳科疾病的个体。
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10.发明申请公开(公告)号：US20110319374A1
公开(公告)日：2011-12-29
申请号：US13190327
申请日：2011-07-25
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
IPC分类号： A61K31/573 , A61P27/16
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
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