公开(公告)号：US5582813A

公开(公告)日：1996-12-10

申请号：US188396

申请日：1994-01-27

申请人： Jean G. Riess ,  Leila Zarif ,  Veronique Sanches ,  Jacques Greiner

发明人： Jean G. Riess ,  Leila Zarif ,  Veronique Sanches ,  Jacques Greiner

IPC分类号： A61K49/04 ,  A61K51/12 ,  B01J13/00

CPC分类号： A61K49/0461 ,  A61K2123/00 ,  Y10S514/938

摘要： The present invention relates to nonterminally iodinated fluorinated compositions. The compositions, including, dispersions, emulsions, microemulsions, and gels are useful for biomedical applications, particularly radiography and scintigraphy. The compounds used in the invention preferably have the following general formula:R.sub.F CH.dbd.CIR.sup.1wherein,R.sub.F is a linear, branched, or cyclic first fluorocarbon radical, having 2 to 12 carbon atoms in which 50 to 100% of the hydrogen atoms have been replaced by fluorine atoms; andR.sup.1 is selected from the group consisting of a second fluorocarbon radical and a hydrocarbon radical, wherein,the second fluorocarbon radical is linear, branched, or cyclic, having 2 to 12 carbon atoms in which 50 to 100% of the hydrogen atoms have been replaced by fluorine atoms; andthe hydrocarbon radical is linear, branched, or cyclic, having 2 to 14 carbon atoms.

摘要翻译： 本发明涉及非最终碘化的氟化组合物。 组合物，包括分散体，乳液，微乳液和凝胶可用于生物医学应用，特别是放射摄影和闪烁扫描。 本发明中使用的化合物优选具有以下通式：RFCH = CIR1其中，RF是具有2至12个碳原子的直链，支链或环状的第一碳氟基，其中50至100％的氢原子已被 氟原子; 并且R 1选自第二氟烃基和烃基，其中，第二氟烃基为直链，支链或环状，具有2至12个碳原子，其中50至100％的氢原子已经被 被氟原子取代; 烃基是直链，支链或环状的，具有2至14个碳原子。