公开(公告)号：US20090258883A1

公开(公告)日：2009-10-15

申请号：US11988424

申请日：2006-07-06

申请人： Jean-Daniel Brion ,  Fabrice Bintein ,  Rodolphe Razet ,  Patrick Razon ,  Zafiarisoa Dolor Renko ,  Eric Levoirier ,  Jean-Francois Pujol ,  Dinah Weissmann ,  Alain Le Ridant ,  Catherine Harpey

发明人： Jean-Daniel Brion ,  Fabrice Bintein ,  Rodolphe Razet ,  Patrick Razon ,  Zafiarisoa Dolor Renko ,  Eric Levoirier ,  Jean-Francois Pujol ,  Dinah Weissmann ,  Alain Le Ridant ,  Catherine Harpey

IPC分类号： A61K31/496 ,  C07D401/12 ,  A61K31/454 ,  A61P25/22 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61K31/4439 ,  C07D401/14

CPC分类号： C07D401/12

摘要： Compounds of formula (I): wherein: A represents a divalent radical: wherein: Z represents an oxygen atom or a sulphur atom, R6 represents a hydrogen atom, an alkyl, alkenyl, arylalkyl or polyhaloalkyl group or a substituted, linear or branched alkyl chain, represents a single bond or a double bond, R1, R2, R3 and R4 represent a hydrogen or halogen atom, an alkyl, alkoxy, hydroxy, cyano, nitro, polyhaloalkyl or optionally substituted amino group, or a linear or branched alkyl chain substituted by one or more groups, R5 represents a hydrogen atom or an alkyl, aminoalkyl or hydroxyalkyl group, X and Y represent a hydrogen atom or an alkyl group, Ra, Rb, Rc and Rd represent a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, cyano, nitro, polyhaloalkyl, optionally substituted amino group, or a substituted, linear or branched alkyl chain, Re represents a hydrogen atom or an alkyl, arylalkyl or alkenyl group or a substituted, linear or branched alkyl chain, their enantiomers, diastereoisomers, and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.

摘要翻译： 式（I）化合物：其中：A表示二价基团：其中：Z表示氧原子或硫原子，R6表示氢原子，烷基，烯基，芳基烷基或多卤代烷基或取代的直链或支链烷基 链接，表示单键或双键，R 1，R 2，R 3和R 4表示氢或卤素原子，烷基，烷氧基，羟基，氰基，硝基，多卤代烷基或任选取代的氨基，或直链或支链烷基链 被一个或多个基团取代，R 5表示氢原子或烷基，氨基烷基或羟烷基，X和Y表示氢原子或烷基，R a，R b，R c和R d表示氢或卤素原子，烷基， 羟基，烷氧基，氰基，硝基，多卤代烷基，任选取代的氨基或取代的直链或支链烷基链， 表示氢原子或烷基，芳基烷基或烯基或取代的直链或支链烷基链，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。