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公开(公告)号:US20090311803A1
公开(公告)日:2009-12-17
申请号:US12544495
申请日:2009-08-20
IPC分类号: G01N33/566
CPC分类号: C07K16/2863 , A61K2039/505 , C07K2317/34 , C07K2317/567 , C07K2317/77
摘要: The invention discloses methods for identifying antibodies that reduce or prevent signaling by intact epidermal growth factor receptor (EGFR), or mutant EGFRs, such as EGFRvIII.
摘要翻译: 本发明公开了用于鉴定减少或预防完整表皮生长因子受体(EGFR)或突变EGFR(如EGFRvIII)的信号传导的抗体的方法。
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公开(公告)号:US20070274991A1
公开(公告)日:2007-11-29
申请号:US11729483
申请日:2007-03-29
IPC分类号: A61K39/395
CPC分类号: C07K16/2863 , A61K2039/505 , C07K2317/34 , C07K2317/567 , C07K2317/77
摘要: The invention discloses methods of treatment of tumors that express oncogenic forms of the epidermal growth factor receptor (EGFR), such as EGFRvIII. The methods include testing of cancer patients for expression of EGFRvIII in their tumors, followed by treatment with a protein that contains antibody variable regions that recognize specific epitopes on the surface of the EGFR.
摘要翻译: 本发明公开了治疗表达EGFR表型生长因子受体(EGFR)的致癌形式的肿瘤的方法。 所述方法包括测试癌症患者在其肿瘤中表达EGFRvIII,随后用包含识别EGFR表面上的特异性表位的抗体可变区的蛋白质进行治疗。
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