公开(公告)号：US06413938B1

公开(公告)日：2002-07-02

申请号：US09367260

申请日：1999-08-25

申请人： Jeffrey H. Tidwell ,  Stanley D. Chamberlain ,  George A. Freeman ,  Joseph H. Chan ,  George W. Koszalka ,  Leroy B. Townsend ,  John C. Drach

发明人： Jeffrey H. Tidwell ,  Stanley D. Chamberlain ,  George A. Freeman ,  Joseph H. Chan ,  George W. Koszalka ,  Leroy B. Townsend ,  John C. Drach

IPC分类号： A61K3170

CPC分类号： C07H19/052 ,  A61K31/7056 ,  Y10S514/934

摘要： According to a first aspect of the invention there is provided compounds of formula (I): wherein: R1 is hydroxy; O-acetyl; or a halo atom; R2 is hydroxy; O-acetyl; or a halo atom; R3 is hydrogen; a halo atom; azido; C2-6alkenyl; C2-6alkynyl; C6-14aryl C2-6alkenyl; C6-14arylC2-6alkynyl —NR8R9 (where R8 and R9 may be the same or different and are hydrogen, C1-8alkyl, cyanoC1-8alkyl, hydroxyC1-8alkyl, haloC1-8alkyl, C3-7cycloalkyl, C1-8alkylC3-7cycloalkyl, C2-6alkenyl, C3-7cycloalkylC1-8alkyl, C2-6alkynyl, C6-14aryl, C6-14arylC1-8alkyl, heterocycleC1-8alkyl, C1-8alkylcarbonyl, C6-14arylsulfonyl, C1-8alkysulfonyl, or R8R9 together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); —OR10 (where R10 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl, C2-6alkenyl, C2-6alkynyl, C6-14aryl C2-6alkenyl or C6-14arylC2-6alkynyl); or —SR11 (where R11 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl).

摘要翻译： 根据本发明的第一方面，提供式（I）的化合物：其中：R 1是羟基; O-乙酰基; 或卤原子; R 2为羟基; O-乙酰基; 或卤素原子; R 3是氢; 卤素原子 叠氮 C2-6烯基; C 2-6炔基; C6-14芳基C2-6烯基; C 6-14芳基C 2-6炔基-NR 8 R 9（其中R 8和R 9可以相同或不同，为氢，C 1-8烷基，氰基C 1-8烷基，羟基C 1-8烷基，卤代C 1-8烷基，C 3-7环烷基，C 1-8烷基C 3-7环烷基， C 1-6烷基，C 3-7环烷基C 1-8烷基，C 2-6炔基，C 6-14芳基，C 6-14芳基C 1-8烷基，杂环C 1-8烷基，C 1-8烷基羰基，C 6-14芳基磺酰基，C 1-8炔基磺酰基或R 8 R 9与它们所连接的N原子一起 形成3,4,5或6元杂环）; -OR 10（其中R 10是氢，C 1-8烷基，C 6-14芳基或C 6-14芳基C 1-8烷基，C 2-6烯基，C 2-6炔基，C 6-14芳基C 2-6烯基或C 6-14芳基C 2-6炔基）; 或-SR 11（其中R 11是氢，C 1-8烷基，C 6-14芳基或C 6-14芳基C 1-8烷基）。