公开(公告)号：US09877761B2

公开(公告)日：2018-01-30

申请号：US14124122

申请日：2012-06-07

申请人： Jeffrey Kapec ,  Kazuna Tanaka ,  Yukiko Naoi ,  Marci Wirtz

发明人： Jeffrey Kapec ,  Kazuna Tanaka ,  Yukiko Naoi ,  Marci Wirtz

IPC分类号： A61B17/88 ,  A61M37/00

CPC分类号： A61B17/8811 ,  A61B17/8825 ,  A61B17/8836 ,  A61M37/00

摘要： Described herein are applicators for delivery of a viscous material to a bone surface and methods of use. The applicator includes an elongate handle portion and a tip coupled to a distal location of the handle portion and formed of an elastomeric material configured to conform to the bone surface. The tip includes a bend a distance away from the distal location, a contact surface distal to the bend and including one or more surface features configured to adhere to the viscous material, and a front end having a conic curvature. The bend is between about 20 degrees to about 40 degrees from a longitudinal axis of the tip.

公开(公告)号：US20150105785A1

公开(公告)日：2015-04-16

申请号：US14124122

申请日：2012-06-07

申请人： Jeffrey Kapec ,  Kazuna Tanaka ,  Yukiko Naoi ,  Marci Wirtz

发明人： Jeffrey Kapec ,  Kazuna Tanaka ,  Yukiko Naoi ,  Marci Wirtz

IPC分类号： A61B17/88

CPC分类号： A61B17/8811 ,  A61B17/8825 ,  A61B17/8836 ,  A61M37/00

摘要： Described herein are applicators for delivery of a viscous material to a bone surface and methods of use. The applicator includes an elongate handle portion and a tip coupled to a distal location of the handle portion and formed of an elastomeric material configured to conform to the bone surface. The tip includes a bend a distance away from the distal location, a contact surface distal to the bend and including one or more surface features configured to adhere to the viscous material, and a front end having a conic curvature. The bend is between about 20 degrees to about 40 degrees from a longitudinal axis of the tip.

摘要翻译： 这里描述了用于将粘性材料输送到骨表面的施用器和使用方法。 施用器包括细长手柄部分和联接到手柄部分的远侧位置并由构造成符合骨表面的弹性体材料形成的尖端。 尖端包括远离远端位置的距离的弯曲部，远离弯曲部的接触表面，并且包括被配置为粘附到粘性材料上的一个或多个表面特征以及具有锥形曲率的前端。 该弯曲部与尖端的纵向轴线成约20度至约40度。

公开(公告)号：US20140066523A1

公开(公告)日：2014-03-06

申请号：US14115219

申请日：2012-05-01

申请人： David Knaack ,  Ankur Gandhi ,  Jordan Katz ,  Marci Wirtz ,  Richard L. Kronenthal

发明人： David Knaack ,  Ankur Gandhi ,  Jordan Katz ,  Marci Wirtz ,  Richard L. Kronenthal

IPC分类号： A61K47/34

CPC分类号： A61K47/34 ,  A61K9/146 ,  A61K31/167

摘要： The invention provides moldable drug delivery carriers made up of a suspension of a solid phase and an organic liquid phase for the sustained release of a therapeutic agent. The invention also provides multiphase drug delivery systems made up of a granular hydrophobic solid phase, an organic liquid phase and a hydrogel, for sustained drug delivery at varying rates over the life of the composition.

摘要翻译： 本发明提供了由固相和有机液相的悬浮液构成的可成形药物递送载体，用于持续释放治疗剂。 本发明还提供由粒状疏水性固相，有机液相和水凝胶组成的多相药物递送系统，用于在组合物的整个使用寿命期间以不同速率持续的药物递送。