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1.发明授权公开(公告)号：US07608406B2
公开(公告)日：2009-10-27
申请号：US10875800
申请日：2004-06-23
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2871
摘要： The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
摘要翻译： 本发明涉及中风和短暂性脑缺血发作的诊断和评估方法。 公开了用于组装用于这种诊断和评估的面板的各种标记。 在各个方面，本发明提供了用于早期检测和分化卒中类型和短暂性脑缺血发作的方法，用于确定患有中风症状的患者的预后，以及鉴定患有脑血管痉挛风险的患者。 本发明方法提供快速，灵敏和特异性的测定以大大增加可以接受有益的中风治疗和治疗的患者的数量，并且降低与不正确的中风诊断相关的成本。
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2.发明申请Use of B-Type Natriuretic Peptide as a Prognostic Indicator in Acute Coronary Syndromes 审中-公开使用B型钠尿肽作为急性冠状动脉综合征的预后指标公开(公告)号：US20110065210A1
公开(公告)日：2011-03-17
申请号：US12874859
申请日：2010-09-02
IPC分类号： G01N33/566
CPC分类号： G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2800/324
摘要： The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
摘要翻译： 本发明涉及用于评估患有急性冠状动脉综合征的患者的预后的材料和程序。 特别地，在患者样品中单独或与一种或多种其他预后标志物组合的BNP或与BNP相关的标志物的水平提供了可用于预测整个频谱中的近期发病率和/或死亡率的预后信息 急性冠状动脉综合征，包括不稳定型心绞痛，非ST段抬高型非Q波心肌梗死，ST段抬高型非Q波心肌梗死和透壁（Q波）MI。
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3.发明授权Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes 有权使用B型利尿钠肽作为急性冠状动脉综合征的预后指标公开(公告)号：US07632647B2
公开(公告)日：2009-12-15
申请号：US09835298
申请日：2001-04-13
IPC分类号： G01N33/53
CPC分类号： G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2800/324
摘要： The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
摘要翻译： 本发明涉及用于评估患有急性冠状动脉综合征的患者的预后的材料和程序。 特别地，在患者样品中单独或与一种或多种其他预后标志物组合的BNP或与BNP相关的标志物的水平提供了可用于预测整个频谱中的近期发病率和/或死亡率的预后信息 急性冠状动脉综合征，包括不稳定型心绞痛，非ST段抬高型非Q波心肌梗死，ST段抬高型非Q波心肌梗死和透壁（Q波）MI。
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4.发明授权公开(公告)号：US07427490B2
公开(公告)日：2008-09-23
申请号：US10225082
申请日：2002-08-20
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N33/573 , G01N2333/96486 , G01N2800/2871 , Y10S436/811
摘要： The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cerebral injury and one or more non-specific markers for cerebral injury. In an alternative aspect, samples are analyzed for B-type natriuretic peptide. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
摘要翻译： 本发明涉及中风和短暂性脑缺血发作的诊断和评估方法。 在特定方面，分析患者样品的一组标志物的存在或量，其包含一种或多种用于脑损伤的特异性标志物和一种或多种用于脑损伤的非特异性标志物。 在另一方面，分析B型利尿钠肽的样品。 公开了用于组装用于这种诊断和评估的面板的各种标记。 在各个方面，本发明提供了用于早期检测和分化卒中类型和短暂性脑缺血发作的方法，用于确定患有中风症状的患者的预后，以及鉴定患有脑血管痉挛风险的患者。 本发明方法提供快速，灵敏和特异性的测定以大大增加可以接受有益的中风治疗和治疗的患者的数量，并且降低与不正确的中风诊断相关的成本。
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